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野麦碱 基本信息
- 中文名称：
- 野麦碱
- 中文别名：
- 野麥鹼;
野麦角碱
- 英文名称：
- Ergoline-8-methanol,8,9-didehydro-6-methyl-
- 英文别名：
- Elymoclavine;
Elymoclavin;
8,9-Didehydro-6-methylergoline-8-methanol
- CAS No.：
- 548-43-6
- 分 子 式：
-
C16H18N2O
- 分 子 量：
- 254.14
- 精确分子量：
- 254.14200
- PSA：
- 39.26000
- EINECS：
- 208-948-9
- InChI：
- The Key: DAVNRFCJMIONPO-UKRRQHHQSA-N
- 危险品标志：
-
- 风险术语：
-
- 安全术语：
- 分子结构式：
-
- SDS：
- 查看
野麦碱 物化性质
- 密度：
- 1.247g/cm3
- 沸点：
- 468ºC at 760mmHg
- 闪点：
- 236.8ºC
- 折射率：
- 1.676
野麦碱 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KE6340000
- CHEMICAL NAME :
- Ergoline-8-methanol, 8,9-didehydro-6-methyl-
- CAS REGISTRY NUMBER :
- 548-43-6
- BEILSTEIN REFERENCE NO. :
- 0030650
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C16-H18-N2-O
- MOLECULAR WEIGHT :
- 254.36
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 128 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BBIADT Biomedica Biochimica Acta. (Akademie-Verlag GmbH, Postfach 1233,
Berlin DDR-1086, Ger. Dem. Rep.) V.42- 1983- Volume(issue)/page/year:
43,1305,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 67 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W.
Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year:
41,1700,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:
58,386,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 222 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BBIADT Biomedica Biochimica Acta. (Akademie-Verlag GmbH, Postfach 1233,
Berlin DDR-1086, Ger. Dem. Rep.) V.42- 1983- Volume(issue)/page/year:
43,1305,1984
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 30 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W.
Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year:
41,1700,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 60 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
- REFERENCE :
- JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W.
Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year:
41,1700,1975
