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马来酸阿扎他啶 基本信息
- 中文名称：
- 马来酸阿扎他啶
- 中文别名：
- 马来酸阿扎他啶;
阿折地平二马来酸盐
- 英文名称：
- Azatadine maleate
- 英文别名：
- azatadine maleate;
Azatadin maleate;
(Z)-but-2-enedioic acid,11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[3,4-b]pyridine;
Azatadine dimaleate;
Idulian;
EINECS 223-615-8;
Zadine;
Azatadine maleate
- CAS No.：
- 3978-86-7
- 分 子 式：
-
C28H30N2O8
- 分 子 量：
- 522.55
- 精确分子量：
- 522.20000
- PSA：
- 165.33000
- EINECS：
- 223-615-8
- InChI：
- InChI=1/C20H22N2.2C4H4O4/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19;2*5-3(6)1-2-4(7)8/h2-7,12H,8-11,13-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
- 危险品标志：
-
- 风险术语：
-
- 安全术语：
- 分子结构式：
-
- SDS：
- 查看
马来酸阿扎他啶 物化性质
- 沸点：
- 450.1ºC at 760 mmHg
- 闪点：
- 226ºC
马来酸阿扎他啶 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DE8025500
- CHEMICAL NAME :
- 11H-Benzo(5,6)cyclohepta(1,2-b)pyridine,
5,6-dihydro-11-(1-methyl-4-piperidylidene)-,
dimaleate
- CAS REGISTRY NUMBER :
- 3978-86-7
- LAST UPDATED :
- 199604
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C20-H22-N2.2C4-H4-O4
- MOLECULAR WEIGHT :
- 522.60
- WISWESSER LINE NOTATION :
- T C676 DN&T&J B1- AT6N CUTJ &QV1U1VQ 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 286 mg/kg/24H-I
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity
- REFERENCE :
- MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd.,
71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914-
Volume(issue)/page/year: 141,449,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 440 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
18,185,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 166 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
1,173,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
1,173,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 165 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70-
Volume(issue)/page/year: 4,264,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 105 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
1,173,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 178 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
1,173,1975
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Gastrointestinal - nausea or vomiting
Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
1,79,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 356 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70-
Volume(issue)/page/year: 4,264,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8400 mg/kg/4W-I
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of endocrine pancreas
Liver - fatty liver degeneration
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
1,173,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 27300 mg/kg/26W-I
- TOXIC EFFECTS :
- Liver - fatty liver degeneration
Musculoskeletal - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
1,173,1975
山东默派生物科技有限公司
- 产品介绍：
-
产品名称：马来酸阿扎他啶
Cas号：3978-86-7
纯度：99%
包装信息：1kg
价格：洽谈
- 联系方式：
-
联系人：谭经理
电话：13053322091
手机：13053322091
杭州鼎燕化工有限公司
- 产品介绍：
-
产品名称：马来酸阿扎他啶
Cas号：3978-86-7
纯度：99%
包装信息：1kg
价格：100.0元
- 联系方式：
-
联系人：Yuri
电话：0571-87157530
手机：18267553885
湖北恩星生物科技有限公司
- 产品介绍：
-
产品名称：马来酸阿扎他啶
Cas号：3978-86-7
纯度：
包装信息：100kg,200kg,300kg,400kg,500kg
价格：64.0元 - 100.0元
- 联系方式：
-
联系人：邵经理
电话：16621771607
手机：16621771607
湖北魏氏化学试剂股份有限公司
- 产品介绍：
-
产品名称：马来酸阿扎他啶
Cas号：3978-86-7
纯度：＞99%
包装信息：25/纸板桶kg
价格：洽谈
- 联系方式：
-
联系人：刘涛
电话：027-59101766
手机：13125137661
钟祥市耀威生物科技有限公司
- 产品介绍：
-
产品名称：马来酸阿扎他啶
Cas号：3978-86-7
纯度：99%
包装信息：1kg,25kg,1kg
价格：洽谈
- 联系方式：
-
联系人：李经理
电话：15337241005
手机：15337241005
武汉鼎信通药业有限公司
- 产品介绍：
-
产品名称：马来酸阿扎他啶
Cas号：3978-86-7
纯度：≥99.0%
包装信息：1/铝箔袋或按需包装kg
价格：洽谈
- 联系方式：
-
联系人：丁亮
电话：027-52344656
手机：15871722230
湖北众善奉行医药科技有限公司
- 产品介绍：
-
产品名称：马来酸阿扎他啶
Cas号：3978-86-7
纯度：98
包装信息：100g
价格：洽谈
- 联系方式：
-
联系人：张丽
电话：027-61907345
手机：13397111514
武汉市维斯尔曼生物工程有限公司
- 产品介绍：
-
产品名称：马来酸阿扎他啶
Cas号：3978-86-7
纯度：99%
包装信息：25kg,1kg,100g,10g,1g
价格：1.0元 - 1.0元
- 联系方式：
-
联系人：王明
电话：027-59402396
手机：13419635609
