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甲硫平 基本信息
- 中文名称：
- 甲硫平
- 中文别名：
- 甲硫平
- 英文名称：
- Dibenzo[b,f][1,4]thiazepine,2-methyl-11-(4-methyl-1-piperazinyl)-
- 英文别名：
- 8-methyl-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine;
11-(N-Methylpiperazino)-2-methyldibenzo-1,4-thiazepin;
2-methyl-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine;
DIBENZO(b,f)(1,4)THIAZEPINE,2-METHYL-11-(4-METHYL-1-PIPERAZINYL);
Metiapine;
Metiapina;
Metiapina [INN-Spanish];
Metiapinum;
3-Methyl-11-(4-methyl-1-piperazinyl)dibenzo<1,4>thiazepin;
Metiapinum [INN-Latin];
2-Methyl-11-(4-methyl-1-piperazinyl)dibenzo(b,f)(1,4)thiazepine
- CAS No.：
- 5800-19-1
- 分 子 式：
-
C19H21N3S
- 分 子 量：
- 323.4551
- 精确分子量：
- 323.14600
- PSA：
- 44.14000
- InChI：
- The Key: IOEPXYJOHIZYGQ-UHFFFAOYSA-N
- 危险品标志：
-
- 风险术语：
-
- 安全术语：
- 分子结构式：
-
- SDS：
- 查看
甲硫平 物化性质
- 密度：
- 1.22g/cm3
- 沸点：
- 473.6ºC at 760mmHg
- 闪点：
- 240.2ºC
- 折射率：
- 1.669
甲硫平 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HQ2275000
- CHEMICAL NAME :
- Dibenzo(b,f)(1,4)thiazepine,
2-methyl-11-(4-methyl-1-piperazinyl)-
- CAS REGISTRY NUMBER :
- 5800-19-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C19-H21-N3-S
- MOLECULAR WEIGHT :
- 323.49
- WISWESSER LINE NOTATION :
- T C676 BS INJ M1 J- AT6N DNTJ D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 934 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
22,334,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 487 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
25,220,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 680 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
22,334,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 320 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
25,220,1973
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 42 mg/kg
- SEX/DURATION :
- female 14 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - menstrual cycle changes or disorders
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
25,212,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 24 mg/kg
- SEX/DURATION :
- female 9-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
25,212,1973
