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布舍瑞林醋酸盐 基本信息
- 中文名称：
- 布舍瑞林醋酸盐
- 中文别名：
- 布舍瑞林醋酸盐;
醋酸布舍瑞林
- 英文名称：
- Buserelinacetate
- 英文别名：
- Buserelin acetate;
Suprecur-MP;
hoe766mp;
Buserecur;
Fuset;
Itorelin;
SupreMon;
hoe766;
EstoMal;
Suprecur;
Suprafact
- CAS No.：
- 68630-75-1
- 分 子 式：
- C60H86N16O13.C2H4O2
- 分 子 量：
- 1299.48
- 精确分子量：
- 1298.68000
- PSA：
- 475.57000
- EINECS：
- 261-061-9
- InChI：
- The Key: PYMDEDHDQYLBRT-DRIHCAFSSA-N
- 风险术语：
- 60
- 分子结构式：
-
- SDS：
- 查看
布舍瑞林醋酸盐 物化性质
- 密度：
- 1.43 g/cm3
- 熔点：
- 186-188°C
布舍瑞林醋酸盐 安全信息
- 危险类别码：
- R60
- 安全说明：
- 53-22-36/37/39-45
- 危险标志：
- T: Toxic;
布舍瑞林醋酸盐 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OK6370000
- CHEMICAL NAME :
- Luteinizing hormone-releasing factor (pig),
6-(O-(1,1-dimethylethyl)-D-serine)-9-(N-ethyl-L-
prolinamide)-10-deglycinamide, monoacetate (salt)
- CAS REGISTRY NUMBER :
- 68630-75-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C60-H86-N16-O13.C2-H4-O2
- MOLECULAR WEIGHT :
- 1299.68
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,831,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Skin and Appendages - hair
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,831,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 36 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex)
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,831,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,831,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Skin and Appendages - hair
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,831,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex)
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,831,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >100 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal)
Gastrointestinal - nausea or vomiting
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,831,1987
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 200 ug/kg
- SEX/DURATION :
- female 1 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - parturition
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 24,265,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 40 ug/kg
- SEX/DURATION :
- female 1 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 24,257,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 378 gm/kg
- SEX/DURATION :
- male 9 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,723,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 35 gm/kg
- SEX/DURATION :
- male 5 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,723,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 10 ug/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - stillbirth
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,631,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 7 ug/kg
- SEX/DURATION :
- female 15-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - stillbirth
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,647,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- DOSE :
- 1700 ug/kg
- SEX/DURATION :
- male 24 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
- REFERENCE :
- FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 57,671,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 130 ug/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,665,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 13 ug/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,665,1987
山东默派生物科技有限公司
- 产品介绍：
-
产品名称：醋酸布舍瑞林
Cas号：68630-75-1
纯度：99%
包装信息：100kg
价格：洽谈
- 联系方式：
-
联系人：谭经理
电话：13053322091
手机：13053322091
淄博航宇生物科技发展有限公司
- 产品介绍：
-
产品名称：布舍瑞林醋酸盐
Cas号：68630-75-1
纯度：99%
包装信息：100kg
价格：洽谈
- 联系方式：
-
联系人：张经理
电话：15666366704
手机：15666366704
南京晟宁医药科技有限公司
- 产品介绍：
-
产品名称：醋酸布舍瑞林
Cas号：68630-75-1
纯度：98%
包装信息：根据客户需求kg
价格：洽谈
- 联系方式：
-
联系人：刘
电话：025-86189919
手机：18168075062
湖北恩星生物科技有限公司
- 产品介绍：
-
产品名称：布舍瑞林醋酸盐
Cas号：68630-75-1
纯度：
包装信息：100kg,200kg,300kg,400kg,500kg
价格：64.0元 - 100.0元
- 联系方式：
-
联系人：邵经理
电话：16621771607
手机：16621771607
成都云希化工有限公司
- 产品介绍：
-
产品名称：布舍瑞林
Cas号：68630-75-1
纯度：98%
包装信息：1克,1克
价格：洽谈
- 联系方式：
-
联系人：罗
电话：18108172074
手机：18108172074
成都云希化工有限公司
- 产品介绍：
-
产品名称：布舍瑞林
Cas号：68630-75-1
纯度：≥98%
包装信息：1g
价格：洽谈
- 联系方式：
-
联系人：程经理
电话：19181987467
手机：19181987467
上海楚肽生物科技有限公司
- 产品介绍：
-
产品名称：布舍瑞林
Cas号：68630-75-1
纯度：98%
包装信息：5mg,100mg,1g,1kg
价格：洽谈
- 联系方式：
-
联系人：吴经理
电话：021-50673982
手机：17321195801
成都云希化工有限公司
- 产品介绍：
-
产品名称：68630-75-1
Cas号：68630-75-1
纯度：95%
包装信息：1g,10g
价格：洽谈
- 联系方式：
-
联系人：李
电话：17380623303
手机：17380623303
湖北东康源医药科技有限公司
- 产品介绍：
-
产品名称：醋酸布舍瑞林
Cas号：68630-75-1
纯度：
包装信息：洽谈
价格：洽谈
- 联系方式：
-
联系人：徐先生
电话：027-81302090
手机：15327141851
