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奎尼定盐酸盐 基本信息
- 中文名称：
- 奎尼定盐酸盐
- 中文别名：
- 奎尼定盐酸盐
- 英文名称：
- Cinchonan-9-ol,6'-methoxy-, hydrochloride (1:1), (9S)-
- 英文别名：
- (S)-[(2R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol,hydrochloride;
Quinidine,monohydrochloride;
EINECS 216-792-8;
Chinidin hydrochlorid
- CAS No.：
- 1668-99-1
- 分 子 式：
-
C20H24N2O2.ClH
- 分 子 量：
- 378.90
- 精确分子量：
- 360.16000
- PSA：
- 45.59000
- EINECS：
- 216-792-8
- InChI：
- The Key: LBSFSRMTJJPTCW-DSXUQNDKSA-N
- 危险品标志：
-
- 风险术语：
-
- 安全术语：
- 分子结构式：
-
- SDS：
- 查看
奎尼定盐酸盐 物化性质
- 沸点：
- 495.9ºC at 760mmHg
- 闪点：
- 253.7ºC
- 蒸汽压：
- 1.19E-10mmHg at 25°C
奎尼定盐酸盐 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VA5750000
- CHEMICAL NAME :
- Quinidine, monohydrochloride
- CAS REGISTRY NUMBER :
- 1668-99-1
- LAST UPDATED :
- 199506
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C20-H24-N2-O2.Cl-H
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 263 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 27,589,1977
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
52,2797,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 27,589,1977
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >125 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
52,2797,1992
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 600 mg/kg/4D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
33,203,1995
