杆菌肽锌

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 结构与计算化学
  • 表征图谱

杆菌肽锌 基本信息

中文名称:
杆菌肽锌 
中文别名:
杆菌肽;
盐酸表柔吡星 
英文名称:
bacitracin
英文别名:
Bacitracin;
BACIDRIN;
ayfivin;
Zutracin;
Baciguen;
Agfivin;
ALTRACIN;
baci-jel;
usafcb-7;
septa;
baciguent 
CAS No.:
1405-87-4
分 子 式:
C66H103N17O16S1
分 子 量:
1422.69
精确分子量:
1421.75000
PSA:
556.17000
MDL:
MFCD00062640
EINECS:
215-786-2
InChI:
InChI=1/C66H103N17O16S/c1-9-35(6)52(69)66-72-32-48(100-66)63(97)80-43(26-34(4)5)59(93)75-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)76-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-73-39)77-60(94)44(27-38-18-
危险品标志:
HarmfulXn
风险术语:
R20/21/22
安全术语:
S22;S24/25;S45;S36;
分子结构式:
SDS:
查看

杆菌肽锌 制备方法及用途

制备方法

生产菌是枯草杆菌。培养基是脱脂大豆粉(5%)、蔗糖(1.2%)、硫酸铵(0.2%)、碳酸钙(0.2%)等。菌的培养过程可分为菌的发育和抗菌素产生两个阶段。产生杆菌肽时的最适宜温度是37℃左右,而细菌发育期的温度则需略高1-2℃,每分钟的通气量为发酵液量的90%。产生的杆菌肽在pH值为4-5.7的条件下,吸附于羧酸型交换树脂上,然后用弱碱(氨)洗脱。由地衣形芽孢杆菌(Bacillus licheni formus)发酵而得。以黄豆粉,淀粉、玉米浸出物、糖蜜和无机盐为培养基,接种5%-10%,发酵30-40h。发酵7-8h后,PH从7.3-7.5降至6.06;发酵初期温度控制在30℃左右,经过2-3h温度提高到37℃。发酵结束后用浓盐酸调PH至5.5,然后在20M3发酵液中加入氧化锌50kg,混合30min。然后进行真空,蒸发浓缩,使干物质含量从4.5%-5%提高到17%-20%,再经喷雾干燥得产品。

合成制备方法

生产菌是枯草杆菌。培养基是脱脂大豆粉(5%)、蔗糖(1.2%)、硫酸铵(0.2%)、碳酸钙(0.2%)等。菌的培养过程可分为菌的发育和抗菌素产生两个阶段。产生杆菌肽时的最适宜温度是37左右,而细菌发育期的温度则需略高1-2,每分钟的通气量为发酵液量的90%。产生的杆菌肽在pH值为4-5.7的条件下,吸附于羧酸型交换树脂上,然后用弱碱(氨)洗脱。

由地衣形芽孢杆菌(Bacillus licheni formus)发酵而得。以黄豆粉,淀粉、玉米浸出物、糖蜜和无机盐为培养基,接种5%-10%,发酵30-40h。发酵7-8h后,PH7.3-7.5降至6.06;发酵初期温度控制在30左右,经过2-3h温度提高到37。发酵结束后用浓盐酸调PH5.5,然后在20M3发酵液中加入氧化锌50kg,混合30min。然后进行真空,蒸发浓缩,使干物质含量从4.5%-5%提高到17%-20%,再经喷雾干燥得产品。

用途简介

该品主要作为动物生长促进剂添加于饲料中。由于有锌、镉、汞盐存在时,该品的活性增强,所以多用该品的锌盐和锰盐作饲料添加剂。生长促进剂是非营养性添加剂,能刺激畜禽生长,提高增重速度和饲料利用率,并增进畜禽健康。该品对多数革兰氏阳性菌有强大的抗菌作用,抗菌与青霉素相似,对青霉素耐药的金葡菌也有效。作为药物主要用于治疗由耐药金葡菌引起的各种感染,如败血症、肺炎、心内膜炎等。

用途

该品主要作为动物生长促进剂添加于饲料中。由于有锌、镉、汞盐存在时,该品的活性增强,所以多用该品的锌盐和锰盐作饲料添加剂。生长促进剂是非营养性添加剂,能刺激畜禽生长,提高增重速度和饲料利用率,并增进畜禽健康。该品对多数革兰氏阳性菌有强大的抗菌作用,抗菌与青霉素相似,对青霉素耐药的金葡菌也有效。作为药物主要用于治疗由耐药金葡菌引起的各种感染,如败血症、肺炎、心内膜炎等。

杆菌肽锌 物化性质

外观与性状:
白色至近乎于白色粉末
密度:
1.43 g/cm3
熔点:
221-225°C
沸点:
1750.1ºC at 760 mmHg
闪点:
1012.2ºC
水溶解性:
可溶
折射率:
1.655
蒸汽压:
0mmHg at 25°C
存储条件/存储方法:
通风低温干燥,与库房食品原料分开存放
稳定性相关:

如果遵照规格使用和储存则不会分解,未有已知危险反应,避免氧化物

其它信息:

1.       性状:灰白色到浅黄色粉末。无臭。味极苦。有吸湿性.

2.       密度(g/mL,25/4):未确定

3.       相对蒸汽密度(g/mL,空气=1):未确定

4.       熔点(ºC):221-225

5.       沸点(ºC,常压):未确定

6.       沸点(ºC,5.2kPa):未确定

7.       折射率:未确定

8.       闪点(ºC):未确定

9.       比旋光度(º):未确定

10.    自燃点或引燃温度(ºC):未确定

11.    蒸气压(kPa,25ºC):未确定

12.    饱和蒸气压(kPa,60ºC):未确定

13.    燃烧热(KJ/mol):未确定

14.    临界温度(ºC):未确定

15.    临界压力(KPa):未确定

16.    油水(辛醇/水)分配系数的对数值:未确定

17.    爆炸上限(%,V/V):未确定

18.    爆炸下限(%,V/V):未确定

19.     溶解性:易溶于水,溶于乙醇、甲醇和冰乙酸,几乎不溶于丙酮、氯仿和乙醚。在酸性溶液中稳定,在pH9以上的碱性溶液中不稳定。

杆菌肽锌 安全信息

海关代码:
2941909000
WGK_Germany:
2
德国有关水污染物质的分类清单
危险类别码:
20/21/22
安全说明:
22-24/25-45-36
RTECS号:
CP0175000
危险标志:
Xn

杆菌肽锌 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CP0175000
CHEMICAL NAME :
Bacitracin
CAS REGISTRY NUMBER :
1405-87-4
LAST UPDATED :
199701

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
190 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1300 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
360 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
>316 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA adduct
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
50 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981 *** REVIEWS *** TOXICOLOGY REVIEW MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.) V.33-115, 1886-1973. Volume(issue)/page/year: 115,1661,1973 TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84423 No. of Facilities: 898 (estimated) No. of Industries: 12 No. of Occupations: 16 No. of Employees: 25810 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9493 No. of Facilities: 266 (estimated) No. of Industries: 5 No. of Occupations: 11 No. of Employees: 15530 (estimated) No. of Female Employees: 14785 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84423 No. of Facilities: 1773 (estimated) No. of Industries: 12 No. of Occupations: 23 No. of Employees: 117226 (estimated) No. of Female Employees: 98652 (estimated)
毒理学数据:

急性毒性:大鼠腹经LD50300mg/kg;小鼠腹经LD50190mg/kg;小鼠口经LD50>3750mg/kg;小鼠皮下LD501300mg/kg;小鼠静脉LD50360mg/kg;天竺鼠口经LD502gm/kg;鹌鹑口经LD50>316mg/kg

生态数据:

对是水稍微有危害的不要让未稀释或大量的产品接触地下水、水道或者污水系统,若无政府许可,勿将材料排入周围环境。

杆菌肽锌 MSDS

Name: Bacitracin Potency Min. 60 units/mg (On the Dry Substance) Material Safety Data Sheet
Synonym: Fortracin; Ayfivin; Baciliquin
CAS: 1405-87-4
Section 1 - Chemical Product   MSDS Name:Bacitracin Potency Min. 60 units/mg (On the Dry Substance) Material Safety Data Sheet
Synonym:Fortracin; Ayfivin; Baciliquin

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
1405-87-4 Bacitracin ca.100 215-786-2
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Hygroscopic (absorbs moisture from the air).The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May cause allergic sensitization in certain individuals.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep refrigerated. (Store below 4C/39F.) Store protected from moisture.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Exposure Limits CAS# 1405-87-4: Russia: 0.01 mg/m3 TWA Personal Protective Equipment Eyes: Wear safety glasses and chemical goggles if splashing is possible.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective gloves and clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Powder
Color: white to gray-yellow
Odor: odorless
pH: 6.0-7.0 (1% aq. sol)
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 221.00 - 225.00 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: soluble
Specific Gravity/Density:
Molecular Formula:
Molecular Weight:

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, alkaline materials, strong oxidants, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, moisture.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 1405-87-4: CP0175000 LD50/LC50:
CAS# 1405-87-4: Oral, mouse: LD50 = >3750 mg/kg.
Carcinogenicity:
Bacitracin - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 1405-87-4: No information available.
Canada
CAS# 1405-87-4 is listed on Canada's DSL List.
CAS# 1405-87-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1405-87-4 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

杆菌肽锌 分子结构与计算化学数据

分子结构数据

1、摩尔折射率:365

2、摩尔体积(cm3/mol):994.4

3、等张比容(90.2K):2761.7

4、表面张力(dyne/cm):59.4

5、介电常数:无可用的

6、极化率(10-24cm3):144.7

7、单一同位素质量:1421.74894 Da

8、标称质量:1421 Da

9、平均质量:1422.6933 Da

计算化学数据

1、   氢键供体数量:16

2、   氢键受体数量:21

3、   可旋转化学键数量:31

4、   互变异构体数量:1001

5、   拓扑分子极性表面积(TPSA):527

6、   重原子数量:101

7、   表面电荷:0

8、   复杂度:2950

9、   同位素原子数量:0

10、   确定原子立构中心数量:0

11、   不确定原子立构中心数量:16

12、   确定化学键立构中心数量:0

13、   不确定化学键立构中心数量:0

14、   共价键单元数量:2

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联系人:黄 电话:027-50662354 手机:13264726139

湖北鑫鸣泰化学有限公司

产品介绍:
产品名称:杆菌肽 Cas号:1405-87-4 纯度:99% 包装信息:25/桶kg 价格:1.0元
联系方式:
联系人:黄经理 电话:027-51833411 手机:13237166274