β-环糊精

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 上游产品
  • 下游产品
  • 表征图谱

β-环糊精 基本信息

中文名称:
β-环糊精 
中文别名:
β-环糊精;
beta-环糊精,B-环糊精;
Beta-环状糊精;
β-环状糊精;
Beta-环糊精;
倍他环糊精、环七糖、环麦芽七糖;
β-Cyclodextrin 
英文名称:
b-Cyclodextrin
英文别名:
β-cyclodextrin;
Cycloglucans;
Cvclodextrin;
betadex;
CARAWAY;
cyclomaltoheptaose;
Klep;
beta-cycloamylose;
beta-Cyclodextrin hydrate;
Cycloheptaglucosan;
FEMA 4028;
cycloheptaamylose;
BW 7;
beta-cyclodextrin;
Celdex N;
CavaMax W 7;
Caraway 
CAS No.:
7585-39-9
分 子 式:

C42H70O35

分 子 量:
1134.98
精确分子量:
1134.37000
PSA:
554.05000
EINECS:
231-493-2
InChI:
The Key: WHGYBXFWUBPSRW-FCJOHOJTSA-N
危险品标志:

IrritantXi

风险术语:

R36/37/38

安全术语:

S26;S36;

分子结构式:
SDS:
查看

β-环糊精 制备方法及用途

制备方法

广泛应用于分离有机化合物及用于有机合成,也用作医药辅料、食品添加剂等。

合成制备方法

一般从柑橘皮、苹果皮、葡萄皮、蚕砂和甜菜渣等植物细胞中用酸解法、酶解法和离子交换法提取。

用途简介

用途

一般从柑橘皮、苹果皮、葡萄皮、蚕砂和甜菜渣等植物细胞中用酸解法、酶解法和离子交换法提取。

β-环糊精 物化性质

外观与性状:
白色粉末
密度:
1.624 g/cm3
熔点:
>260ºC (dec.)(lit.)
沸点:
1578.5ºC at 760 mmHg
闪点:
908.5ºC
其它信息:

一、物性数据

1.             性状:白色至淡黄色粉末,稍有果胶特有香气,味微甜且略带酸味。

2.             密度(g/mL,25/4℃):0.7

3.             相对蒸汽密度(g/mL,空气=1):不确定

4.             熔点(ºC):116

5.             沸点(ºC,0.67kpa或5 mmHg):不确定

6.             折射率:不确定

7.             闪点(ºC):不确定

8.             比旋光度(ºC):不确定

9.             自燃点或引燃温度(ºC)不确定

10.          蒸气压(kPa,25ºC):不确定

11.          饱和蒸气压(kPa,60ºC):不确定

12.          燃烧热(KJ/mol):不确定

13.          临界温度(ºC):不确定

14.          临界压力(KPa):不确定

15.          油水(辛醇/水)分配系数的对数值:不确定

16.          爆炸上限(%,V/V):不确定

17.          爆炸下限(%,V/V):不确定

18.          溶解性:能溶于水,不溶于乙醇和其他有机溶剂。

β-环糊精 安全信息

海关代码:
3505100000
危险类别码:
R36/37/38
安全说明:
S26-S36
安全标志:
S24/25:防止皮肤和眼睛接触。
危险标志:
Xi

β-环糊精 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GU2293000
CHEMICAL NAME :
beta-Cyclodextrin
CAS REGISTRY NUMBER :
7585-39-9
LAST UPDATED :
199710
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C42-H70-O35
MOLECULAR WEIGHT :
1135.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 26,287,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
356 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
48THAM "Proceedings of the International Symposium on Cyclodextrins, 1st, 1981," Szejtli, J., ed., Hingham, MA, Kluwer Academic Pub., 1982 Volume(issue)/page/year: 1,109,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 26,287,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1008 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925- Volume(issue)/page/year: 83,367,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>12500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSSCBG Pesticide Science. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1970- Volume(issue)/page/year: 11,134,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
330 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
48THAM "Proceedings of the International Symposium on Cyclodextrins, 1st, 1981," Szejtli, J., ed., Hingham, MA, Kluwer Academic Pub., 1982 Volume(issue)/page/year: 1,109,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
412 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
48THAM "Proceedings of the International Symposium on Cyclodextrins, 1st, 1981," Szejtli, J., ed., Hingham, MA, Kluwer Academic Pub., 1982 Volume(issue)/page/year: 1,109,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
634 gm/kg/52W-C
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 33,367,1995 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
350 gm/kg
SEX/DURATION :
multigeneration
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 9,389,1995 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2627 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 123 (estimated) No. of Female Employees: 123 (estimated)

β-环糊精 MSDS

Name: Beta-Cyclodextrin Material Safety Data Sheet
Synonym: Cycloheptaamylose; Alpha-3-Schardinger Dextrin; C
CAS: 7585-39-9
Section 1 - Chemical Product   MSDS Name:Beta-Cyclodextrin Material Safety Data Sheet
Synonym:Cycloheptaamylose; Alpha-3-Schardinger Dextrin; C

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
7585-39-9 Beta-Cyclodextrin hydrate ca.100% 231-493-2
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 7585-39-9: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Crystalline powder
Color: white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 310 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C42H70O35
Molecular Weight: 1135.00

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 7585-39-9: GU2293000 LD50/LC50:
CAS# 7585-39-9: Oral, mouse: LD50 = >12500 mg/kg; Oral, rat: LD50 = 18800 mg/kg.
Carcinogenicity:
Beta-Cyclodextrin hydrate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 7585-39-9: 0
Canada
CAS# 7585-39-9 is listed on Canada's DSL List.
CAS# 7585-39-9 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 7585-39-9 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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