L-色氨酸

密度：

1.34

熔点：

289-290 °C (dec.)(lit.)

水溶解性：

11.4 g/L (25 °C)

存储条件/存储方法：

密封阴凉干燥避光保存

稳定性相关：

1.长时间光照则着色。与水共热产生少量吲哚，如在氢氧化钠、硫酸铜存在下加热，则产生多量吲哚。与酸在暗处加热较稳定。与其他氨基酸、糖类、醛类共存时极易分解。

2. 存在于白肋烟烟叶、烟气中。

其它信息：

1.       性状：有三种异构体。左旋体是片状晶体，无味。

2.       密度（g/mL,25/4℃）：1.362

3.       相对蒸汽密度（g/mL,空气=1）：不确定

4.       熔点（ºC）：289-290 (dec.)(lit.)

5.       沸点（ºC,常压）：不确定

6.       沸点（ºC, 5.2 kPa）：不确定

7.       折射率：-32 ° (C=1, H2O)

8.       闪点（ºC）：不确定

9.       比旋光度（º）：-31.1 º (c=1, H20)

10.    自燃点或引燃温度（ºC）：不确定

11.    蒸气压（kPa,25 ºC）：不确定

12.    饱和蒸气压（kPa,60 ºC）：不确定

13.    燃烧热（KJ/mol）：不确定

14.    临界温度（ºC）：不确定

15.    临界压力（KPa）：不确定

16.    油水（辛醇/水）分配系数的对数值：不确定

17.    爆炸上限（%,V/V）：不确定

18.    爆炸下限（%,V/V）：不确定

19.    溶解性：在水中微溶（1.14%, 25℃)和乙醇。 可溶于稀酸或稀碱(20% NH₃: 0.1 g/mL at 20 °C, clear, colorless) ，不溶于氯仿、乙醚

海关代码：

2933990090

危险类别码：

33-40-62-41-37/38-36/37/38-22

安全说明：

24/25-36/37/39-36-26

安全标志：

S24/25:防止皮肤和眼睛接触。
S22:不要吸入粉尘。

CHEMICAL IDENTIFICATION

RTECS NUMBER :

YN6130000

CHEMICAL NAME :

Tryptophan, L-

CAS REGISTRY NUMBER :

73-22-3

LAST UPDATED :

199701

DATA ITEMS CITED :

29

MOLECULAR FORMULA :

C11-H12-N2-O2

MOLECULAR WEIGHT :

204.25

WISWESSER LINE NOTATION :

T56 BMJ D1YZVQ -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

10960 mg/kg/20W-I

TOXIC EFFECTS :

Behavioral - muscle weakness Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - eosinophilia

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

2700 mg/kg/13W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - acute pulmonary edema Blood - eosinophilia

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

3276 mg/kg/9W-I

TOXIC EFFECTS :

Behavioral - muscle weakness Blood - eosinophilia Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

9 gm/kg/22W-I

TOXIC EFFECTS :

Behavioral - muscle weakness Liver - liver function tests impaired Blood - eosinophilia

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

300 mg/kg

TOXIC EFFECTS :

Behavioral - excitement Behavioral - antianxiety

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

857 mg/kg/30D-I

TOXIC EFFECTS :

Blood - eosinophilia Musculoskeletal - other changes Skin and Appendages - other glands

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

4800 mg/kg/34W-I

TOXIC EFFECTS :

Peripheral Nerve and Sensation - paresthesis Blood - eosinophilia Skin and Appendages - other glands

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

5400 mg/kg/134W-I

TOXIC EFFECTS :

Blood - eosinophilia Skin and Appendages - other glands

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>16 gm/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - ptosis Behavioral - coma Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1634 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2553 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

15 gm/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - ptosis Lungs, Thorax, or Respiration - cyanosis Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

4800 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Bird - domestic

DOSE/DURATION :

2410 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

72 gm/kg/30D-C

TOXIC EFFECTS :

Liver - changes in liver weight Kidney, Ureter, Bladder - urine volume increased Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

30 gm/kg/30D-I

TOXIC EFFECTS :

Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

9500 mg/kg/2Y-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Implant

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

80 mg/kg

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

200 mg/kg

SEX/DURATION :

female 18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

900 mg/kg

SEX/DURATION :

female 3 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

MUTATION DATA

TYPE OF TEST :

DNA inhibition

TEST SYSTEM :

Rodent - rat Liver

DOSE/DURATION :

100 umol/L

REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,337,1985 *** REVIEWS *** TOXICOLOGY REVIEW BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 24,253,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3075 No. of Facilities: 1257 (estimated) No. of Industries: 6 No. of Occupations: 19 No. of Employees: 24809 (estimated) No. of Female Employees: 18622 (estimated)

中国海关编码：2933990090

概述：

2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

申报要素：

品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

摘要/Summary：

2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

分子结构数据

五、分子性质数据：

1、   摩尔折射率：57.76

2、   摩尔体积（cm³/mol）：149.8

3、   等张比容（90.2K）：435.3

4、   表面张力（dyne/cm）：71.1

5、   极化率（10^-24cm³）：22.90

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:3

3.氢键受体数量:3

4.可旋转化学键数量:3

5.互变异构体数量:无

6.拓扑分子极性表面积79.1

7.重原子数量:15

8.表面电荷:0

9.复杂度:245

10.同位素原子数量:0

11.确定原子立构中心数量:1

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

• 
  L-色胺酸红外图谱(IR1)
• 
  L-色胺酸红外图谱(IR2)
• 
  L-色胺酸质谱(MS)
• 
  L-色胺酸核磁图(¹³CNMR)
• 
  L-色胺酸核磁图(¹HNMR)