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三甲利定 基本信息
- 中文名称：
- 三甲利定
- 中文别名：
- 三甲利定
- 英文名称：
- trimeperidine
- 英文别名：
- [(2S,5R)-1,2,5-trimethyl-4-phenylpiperidin-4-yl] propanoate;
EINECS 200-583-3;
trimeperidine;
DEA No. 9646;
1,2,5-trimethyl-4-phenyl-4-propionyloxy-piperidine;
Promedol;
4-Piperidinol,4-phenyl-1,2,5-trimethyl-,propionate;
1,2,5-Trimethyl-4-phenyl-4-propionoxypiperidine;
Isopromedol
- CAS No.：
- 64-39-1
- 分 子 式：
- C17H25NO2
- 分 子 量：
- 275.389
- 精确分子量：
- 275.18900
- PSA：
- 29.54000
- InChI：
- The Key: UVITTYOJFDLOGI-KEYYUXOJSA-N
- 分子结构式：
-
- SDS：
- 查看
三甲利定 物化性质
- 密度：
- 1.04g/cm3
- 沸点：
- 348.2ºC at 760 mmHg
- 闪点：
- 109ºC
- 折射率：
- 1.53
三甲利定 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TN8000000
- CHEMICAL NAME :
- 4-Piperidinol, 1,2,5-trimethyl-4-phenyl-, propionate
(ester)
- CAS REGISTRY NUMBER :
- 64-39-1
- LAST UPDATED :
- 199803
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C17-H25-N-O2
- MOLECULAR WEIGHT :
- 275.43
- WISWESSER LINE NOTATION :
- T6NTJ A B DOV2 DR&E
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 38 mg/kg
- TOXIC EFFECTS :
- Behavioral - analgesia
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-
1967- Volume(issue)/page/year: 14,850,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 22 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-
1967- Volume(issue)/page/year: 8,189,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 33 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,23,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 117 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-
1967- Volume(issue)/page/year: 23,395,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-
1967- Volume(issue)/page/year: 10,1193,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 38 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
UK) V.30- 1967- Volume(issue)/page/year: 31,318,1968
