基本信息
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吡柔比星
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72496-41-4
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吡柔比星
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C32H37NO12
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627.64
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5,12-Naphthacenedione,10-[[3-amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-
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1.51 g/cm3
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5,12-Naphthacenedione,10-[[3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,[8S-[8a,10a(S*)]]-; 5,12-Naphthacenedione,10-[[3-amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,(8S,10S)- (9CI); (2''R)-4'-O-Tetrahydropyranyladriamycin;(2''R)-4'-O-Tetrahydropyranyldoxorubicin; 4'-O-Tetrahydropyranyladriamycin;Pinorubicin; Pirarubicin; THP-Adriamycin; Therarubicin
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458.586 °C
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188-192ºC (dec.)
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834.7ºC at 760 mmHg
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详细信息
中文名称： 吡柔比星
英文名称： Pirarubicin
英文别名： Pirarubicin [INN:JAN]; (2''''R)-4''-O-Tetrahydropyranyladriamycin; (8S,10S)-10-((3-Amino-2,3,6-trideoxy-4-O-(2R-tetrahydro-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl)oxy)-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; 1609RB; 4''-O-Tetrahydropyranyladriamycin; 4''-O-Tetrahydropyranyldoxorubicin; Pirarubicina; Pirarubicina [Spanish]; Pirarubicine; Pirarubicine [French]; Pirarubicinum; Pirarubicinum [Latin]; THP-adriamycin; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-4-O-[(2S)-tetrahydro-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranoside; (3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranoside; Pirarubicin Hydrochloride
CAS号： 72496-41-4
分子式： C32H37NO12
分子量： 627.6357
分子结构：
密度： 1.51g/cm3
沸点： 834.7°C at 760 mmHg
闪点： 458.6°C
蒸汽压： 1.51E-29mmHg at 25°C
性状：为白色至淡黄色冻干疏松块状物
产品用途：抗肿瘤原料药-细胞毒类药物-作用于DNA化学结构的药物
能迅速进入癌细胞,通过抑制核酸合成阻止细胞分裂,主要作用于G2期
对心脏、骨髓抑制的毒副作用较阿霉素小
生产方法：由阿霉素和二氢吡喃合成的蒽环类抗肿瘤抗生素。
储运条件：存放在密封容器内,并放在阴凉,干燥处。2-8 oC保存。
