基本信息
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盐酸去甲金霉素
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64-73-3
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去甲基金霉素;7-氯-4-二甲氨基-3,6,10,12,12a-五羟基-1,11-二氧代-1,4,4a,5,5a,6,11,12a-八氢-2-并四苯甲酰胺盐酸盐;盐酸地美环素;地美环素盐酸盐;脱甲氯四环素;地美环素;盐酸去甲基金霉素
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C21H21ClN2O8.ClH
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501.32
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2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)-
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200-592-2
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2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,monohydrochloride (8CI); 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,monohydrochloride, (4S,4aS,5aS,6S,12aS)- (9CI); 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,monohydrochloride, [4S-(4a,4aa,5aa,6b,12aa)]-; 6-Demethyl-7-chlorotetracyclinehydrochloride;7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamidemonohydrochloride; 7-Chloro-6-demethyltetracycline hydrochloride; Clortetrin;Declomycin; Declomycin hydrochloride; Demeclocycline hydrochloride;Demethylchlorotetracycline hydrochloride; Demetraciclina; Detravis; Ledermycinhydrochloride; Meciclin
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435.2oC
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>245°C (dec.)
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795.9oC at 760 mmHg
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急性毒性：人口经LDLo：69 mg/kg/4D-I；大鼠口经LD50：2372 mg/kg；大鼠静脉LD50：94 mg/kg； 小鼠口经LD50：2150 mg/kg；小鼠静脉LD50：275 mg/kg；繁殖：大鼠子宫TDLo：50 mg/kgSEX/DURATION : female 1 day(s) pre-mating；&nb
详细信息
盐酸去甲金霉素为广谱抑菌剂，作用与四环素相同。四环素类是主要抑制细菌蛋白质合成的广谱抗生素，高浓度具有杀菌作用。其抗菌谱广，对革兰氏阴性需氧菌和厌氧菌、立克次体、螺旋体、支原体、衣原体及某些原虫等有抗菌作用。四环素类抗生素抗菌活性相似，但米诺霉素和多西环素对耐四环素菌株有强大的抗菌活性。
