Blasticidin S is an aminoacylnucleoside antibiotic isolated from Streptomyces griseochromogenes. It shows high efficacy against both eukaryotic prokaryotic cells. Aside from its antimicrobial properties, blasticidin has displayed antiviral, antitumor, antifungal properties has been used as aion agent. It has been used to fcells containing the bls, bsr, BSD resistance gene as well as HEK293-T cells HEK-D5 cells. Additionally, blasticidin is effective in preventing cell culture contamination studying protein synthesis.
Blasticidin S functions by inhibiting peptide bond formation at the ribosome. It blocks hydrolysis of peptidyl-tRNA due to the large ribosomal subunit's increased affinity ftRNA.
Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative gram-positive bacteria using panels, discs, MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, the results are used in clinical settings to determine which antibiotic(s) to prescribe fvarious infections.
Product Specifications
Blasticidin S HCl
Blasticidin S Hydrochloride
Formula: C17H26N8O5 HCl
MW: 458.9 g/mol
Storage/Handling: Store desiccated at -20°C.
PubChem Chemical ID 16760315
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