U0126，109511-58-2,>98%_爱必信(上海) 生物科技有限公司

U0126，109511-58-2(109511-58-2)

现现货供应

CAS NO：: 109511-58-2

纯度：: >98%

规格：: 5mg瓶,10mg瓶,25mg瓶,50mg瓶,100mg瓶

价格：: 400.0元 - 3,200.0元

: 马上询价

基本信息

产品名称：1,4-二氨基-2,3-二氰基-1,4-双(邻氨基苯巯基)丁二烯
CAS NO：109511-58-2
中文别名：
分子式：
C₁₈H₁₆N₆S₂
分子量：380.49
英文名称：Butanedinitrile,2,3-bis[amino[(2-aminophenyl)thio]methylene]-
EINECS：
密度：1.44 g/cm³
英文别名：Butanedinitrile,bis[amino[(2-aminophenyl)thio]methylene]- (9CI); Succinonitrile, bis[amino(o-aminophenylthio)methylene]-(6CI); U 0126; UO 126
闪点：295.6 ºC
熔点：approximate 154℃(dec.)
沸点：565.1 ºC at 760 mmHg
毒性：

详细信息

概述
描述	U-0126 is aive MAP Kinase Kinase inhibitor, displaying a preference fMEK-1 (IC50 = 72 nM) MEK-2 (IC50 58nM). It is known that U-0126 binds to MEK in a noncompetitive manner compared to ATP. Studies suggest that U-0126 antagonizes the transcription of AP-1, via the inhibition of MEK. In addition, U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activatof PGC-1, mtTFA nuclear respiratory factor.
别名	U0126，U 0126

概述

描述

U-0126 is aive MAP Kinase Kinase inhibitor, displaying a preference fMEK-1 (IC50 = 72 nM) MEK-2 (IC50 58nM). It is known that U-0126 binds to MEK in a noncompetitive manner compared to ATP. Studies suggest that U-0126 antagonizes the transcription of AP-1, via the inhibition of MEK. In addition, U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activatof PGC-1, mtTFA nuclear respiratory factor.

别名

U0126，U 0126

性能
外观	Lyophilized powder
保存方法	store at -20℃ fone year（Powder）； in DMSO others solvent store at 2-4℃ ftwo weeks, at -20℃ fsix months.
纯度	>98%
分子量	380.48
分子结构式
化学式	C₁₈H₁₆N₆S₂
溶解性	Soluble in DMSO at 200 mg/mL
CAS号	109511-58-2