乙二醇乙醚乙酸酯

外观与性状：

无色液体

密度：

0.975 g/mL at 25 °C(lit.)

熔点：

-61 °C

沸点：

156 °C(lit.)

闪点：

135 °F

水溶解性：

230 g/L (20 ºC)

折射率：

n20/D 1.406(lit.)

蒸汽压：

0.16kPa/20°C

蒸汽密度：

4.6 (vs air)

存储条件/存储方法：

库房通风低温干燥,与氧化剂分开存放

稳定性相关：

1.能与一般有机溶剂混溶，溶于水。有令人愉快的酯类香。作为新一代万能溶剂，具有极强的溶解能力，尤其对聚合物高分子的溶解力更强。具有脂肪族醚和乙酸酯的性质。

2.稳定性^[21]  稳定

3.禁配物^[22]  酸类、碱类、强氧化剂

4.聚合危害^[23]  不聚合

其它信息：

1.性状：无色液体，有微弱的类似芳香脂的气味。^[1]

2.熔点（℃）：-61.7^[2]

3.沸点（℃）：156.4^[3]

4.相对密度（水=1）：0.97（20℃）^[4]

5.相对蒸气密度（空气=1）：4.72^[5]

6.饱和蒸气压（kPa）：0.27（20℃）^[6]

7.燃烧热（kJ/mol）：-3304.5^[7]

8.临界温度（℃）：334^[8]

9.临界压力（MPa）：3.0^[9]

10.辛醇/水分配系数：0.65^[10]

11.闪点（℃）：47（OC）；52（CC）^[11]

12.引燃温度（℃）：379^[12]

13.爆炸上限（%）：14^[13]

14.爆炸下限（%）：1.7^[14]

15.溶解性：微溶于水，溶于乙醇、乙醚，可混溶于芳烃等多数有机溶剂。^[15]

16.折射率（25ºC）：1.4023 

17.折射率（30ºC）：1.4003

18.黏度（mPa·s,25ºC）：1.025

19.闪点（ºC,闭口）：51

20.闪点（ºC,开口）：66

21.蒸气压（kPa,20ºC）：0.15

22.蒸气压（kPa,48ºC）：1.33

23.蒸气压（kPa,81ºC）：6.67

24.蒸发热（KJ/mol）：44.4

25.比热容（KJ/(kg·K),20ºC,定压）：2.07

26.电导率（S/m）：2×10^-8

27.体膨胀系数（K^-1,10~30ºC）：0.00111

包装等级：

III

风险类别：

3

海关代码：

2915390090

WGK_Germany：

1
德国有关水污染物质的分类清单

危险类别码：

R10;R20/21/22;R60;R61

安全说明：

S53-S45

RTECS号：

KK8225000

安全标志：

S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S53:避免暴露——使用前先阅读专门的说明。

危险标志：

T:Toxic

CHEMICAL IDENTIFICATION

RTECS NUMBER :

KK8225000

CHEMICAL NAME :

Ethanol, 2-ethoxy-, acetate

CAS REGISTRY NUMBER :

111-15-9

BEILSTEIN REFERENCE NO. :

1748677

LAST UPDATED :

199712

DATA ITEMS CITED :

59

MOLECULAR FORMULA :

C6-H12-O3

MOLECULAR WEIGHT :

132.18

WISWESSER LINE NOTATION :

2O2OV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Open irritation test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/13/1967

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/13/1967 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2700 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(10),78,1988

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

12100 mg/m3/8H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 20,364,1959

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1420 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,2,1961

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

5 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 42,355,1931

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

1950 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0682-0450

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

>2000 ppm/4H

TOXIC EFFECTS :

Kidney, Ureter, Bladder - hematuria

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 51,117,1979

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

10500 uL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/13/1967

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

1910 mg/kg

TOXIC EFFECTS :

Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :

JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

>19460 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0682-0450 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

600 ppm/7H

SEX/DURATION :

female 7-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :

EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0682-0450

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

200 ppm/6H

SEX/DURATION :

female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - respiratory system

REFERENCE :

FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 10,20,1988

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

300 ppm/6H

SEX/DURATION :

female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

UCRR** Union Carbide Research Report. (Union Carbide Corp., Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 09OCT1984

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

50 mg/kg/4H

SEX/DURATION :

female 1-19 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :

FAVUAI Fiziologicheski Aktivnye Veshchestva. Physiologically Active Substances. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1966- Volume(issue)/page/year: 21,30,1989

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

50 ppm/6H

SEX/DURATION :

female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :

UCRR** Union Carbide Research Report. (Union Carbide Corp., Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 09OCT1984

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Administration onto the skin

DOSE :

70 gm/kg

SEX/DURATION :

female 7-16 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :

EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 57,69,1984

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Administration onto the skin

DOSE :

70 gm/kg

SEX/DURATION :

female 7-16 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

REFERENCE :

EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 57,69,1984

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

25 gm/kg

SEX/DURATION :

male 25 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :

SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959- Volume(issue)/page/year: 21,29,1979

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

100 gm/kg

SEX/DURATION :

male 25 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :

SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959- Volume(issue)/page/year: 21,29,1979

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

200 ppm/6H

SEX/DURATION :

female 6-18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - respiratory system Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

UCRR** Union Carbide Research Report. (Union Carbide Corp., Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 09OCT1984

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

200 ppm/6H

SEX/DURATION :

female 6-18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :

UCRR** Union Carbide Research Report. (Union Carbide Corp., Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 09OCT1984

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

100 ppm/6H

SEX/DURATION :

female 6-18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :

UCRR** Union Carbide Research Report. (Union Carbide Corp., Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 09OCT1984

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

100 ppm/6H

SEX/DURATION :

female 6-18 day(s) after conception

REFERENCE :

EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 57,33,1984 *** REVIEWS *** ACGIH TLV-TWA 27 mg/m3 (5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 100 ppm (540 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,101,1971 OSHA PEL (Gen Indu):8H TWA 100 ppm (540 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 100 ppm (540 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 100 ppm (540 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 100 ppm (540 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (27 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 5 ppm (27 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (27 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 50 ppm (270 mg/m3);STEL 100 ppm (540 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (27 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 20 ppm (110 mg/m3);Skin JAN 1993 OEL-HUNGARY:TWA 25 mg/m3;STEL 50 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 5 ppm (27 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (27 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 100 ppm (540 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 100 mg/m3 JAN 1993 OEL-RUSSIA:TWA 5 ppm JAN 1993 OEL-SWEDEN:TWA 5 ppm (30 mg/m3);STEL 10 ppm (50 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (27 mg/m3);STEL 10 ppm (54 mg/m3);Skin JAN 1993 OEL-TURKEY:TWA 100 ppm (540 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (54 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO EGEEA-air:10H TWA 0.5 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4063 No. of Facilities: 38895 (estimated) No. of Industries: 228 No. of Occupations: 127 No. of Employees: 321063 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4063 No. of Facilities: 16901 (estimated) No. of Industries: 149 No. of Occupations: 103 No. of Employees: 265104 (estimated) No. of Female Employees: 51020 (estimated)

毒理学数据：

1.急性毒性^[16]

LD50：2900mg/kg（大鼠经口）；10500μl（10185mg）/kg（兔经皮）

LC50：12100mg/m³（大鼠吸入，8h）

2.刺激性^[17]

家兔经皮：490mg，轻度刺激（开放性刺激试验）。

家兔经眼：40mg，中度刺激。

生态数据：

1.生态毒性^[18]  LC50：43.5mg/L（48h），42.2mg/L（96h）（黑头呆鱼）

2.生物降解性^[19]  MITI-I测试，初始浓度100ppm，污泥浓度30ppm，2周后降解86.9%。

3.非生物降解性^[20]  空气中，当羟基自由基浓度为5.00×10⁵个/cm³时，降解半衰期为1.5d（理论）。

当pH值为7，8时，水解半衰期分别为305d，30d（理论）。

中国海关编码：2915390090

概述：

2915390090. 其他乙酸酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%

申报要素：

品名, 成分含量, 用途

监管条件：

A.入境货物通关单B.出境货物通关单

检验检疫：

R.进口食品卫生监督检验S.出口食品卫生监督检验M.进口商品检验N.出口商品检验

摘要/Summary：

2915390090. esters of acetic acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:5.5%. General tariff:30.0%

分子结构数据

1、摩尔折射率：33.36

2、摩尔体积（cm³/mol）：137.4

3、等张比容（90.2K）：315.2

4、表面张力（dyne/cm）：27.6

5、极化率（10^-24cm³）：13.22

计算化学数据

1.疏水参数计算参考值（XlogP）:0.3

2.氢键供体数量:0

3.氢键受体数量:3

4.可旋转化学键数量:5

5.互变异构体数量:无

6.拓扑分子极性表面积35.5

7.重原子数量:9

8.表面电荷:0

9.复杂度:80.4

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

• 
  乙二醇乙醚醋酸酯核磁图(¹HNMR)
• 
  乙二醇乙醚醋酸酯Raman光谱
• 
  乙二醇乙醚醋酸酯核磁图(¹³CNMR)
• 
  乙二醇乙醚醋酸酯质谱(MS)
• 
  乙二醇乙醚醋酸酯红外图谱(IR1)