二甲亚砜

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • 结构与计算化学
  • 上游产品
  • 下游产品
  • 表征图谱

二甲亚砜 基本信息

中文名称:
二甲亚砜 
中文别名:
二甲基亚砜;
二甲基亞碸;
二甲基 
英文名称:
Dimethyl sulfoxide
英文别名:
dimethyl sulfoxide;
Dimethyl sulfoxide;
(Methylsulfinyl)methane 
CAS No.:
67-68-5
分 子 式:

C2H6OS

分 子 量:
78.12
精确分子量:
78.01390
PSA:
36.28000
MDL:
MFCD00002089
EINECS:
200-664-3
BRN:
506008
InChI:
InChI=1/C2H6OS/c1-4(2)3/h1-2H3
危险品标志:

irritantxi

风险术语:

R36/37/38

安全术语:

S26; S37/39

分子结构式:
SDS:
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二甲亚砜 制备方法及用途

制备方法

二甲基亚砜一般采用二甲硫醚氧化法制得,由于所用的氧化剂和氧化方式不同,因而有不同的生产工艺。1.甲醇二硫化碳法甲醇和二硫化碳为原料,以γ-Al2O3作催化剂,先合成二甲基硫醚,再与二氧化氮(或硝酸)氧化得二甲基亚砜。2.双氧水法 以丙酮作缓冲介质,使二甲硫醚与双氧水反应。用该法生产二甲基亚砜成本较高,不适于大规模生产。3.二氧化氮法 以甲醇和硫化氢在γ-氧化铝作用下生成二甲基硫醚;硫酸与亚硝酸钠反应生成二氧化氮;二甲基硫醚再与二氧化氮在60-80℃进行气液相氧化反应生成粗二甲基亚砜,也有直接用氧气进行氧化,同样生成粗二甲基亚砜,然后经减压蒸馏,精制得二甲基亚砜成品。此法是较为先进的生产方法。4.硫酸二甲酯法用硫酸二甲酯与硫化钠反应,制得二甲基硫醚;硫酸与亚硝酸钠反应生成二氧化氮;二甲基硫醚与二氧化氮氧化得粗二甲基亚砜,再经中和处理,蒸馏后得精二甲基亚砜。此外,用阳极氧化的方法由二甲硫醚生产二甲基亚砜。 精制方法:将二甲亚砜减压蒸馏后,加入氧化铝放置一夜,用高50cm,填有陶制鞍形填料的蒸馏塔,于266.6~399.9Pa、50℃进行减压蒸馏,收集中间馏分。或将二甲亚砜与CaH2一起加热一日,减压蒸馏后用分子筛干燥,在氮气流下再进行减压蒸馏。也可以分步结晶精制。5.将二甲硫醚 ( 由硫酸二甲酯与硫化钠反应制得)与二氧化氮( 由硫酸与亚硝酸钠反应制得)在60~80℃进行气液相氧化反应制得二甲基亚砜粗品,然后减压蒸馏、采用分子筛脱水后再减压精馏,即得成品二甲基亚砜。主要反应式为: 6.以丙酮作为缓冲介质,加入相等物质量的二甲硫醚和双氧水,搅拌反应,维持温度20℃: 反应结束后,直接减压蒸馏即可得纯度较高的二甲基亚砜。

合成制备方法

二甲基亚砜一般采用二甲硫醚氧化法制得,由于所用的氧化剂和氧化方式不同,因而有不同的生产工艺。
1.甲醇二硫化碳法甲醇和二硫化碳为原料,以γ-Al2O3作催化剂,先合成二甲基硫醚,再与二氧化氮(或硝酸)氧化得二甲基亚砜。


2.双氧水法 以丙酮作缓冲介质,使二甲硫醚与双氧水反应。用该法生产二甲基亚砜成本较高,不适于大规模生产。
3.二氧化氮法 以甲醇和硫化氢在γ-氧化铝作用下生成二甲基硫醚;硫酸与亚硝酸钠反应生成二氧化氮;二甲基硫醚再与二氧化氮在60-80℃进行气液相氧化反应生成粗二甲基亚砜,也有直接用氧气进行氧化,同样生成粗二甲基亚砜,然后经减压蒸馏,精制得二甲基亚砜成品。此法是较为先进的生产方法。


4.硫酸二甲酯法用硫酸二甲酯与硫化钠反应,制得二甲基硫醚;硫酸与亚硝酸钠反应生成二氧化氮;二甲基硫醚与二氧化氮氧化得粗二甲基亚砜,再经中和处理,蒸馏后得精二甲基亚砜。此外,用阳极氧化的方法由二甲硫醚生产二甲基亚砜。

精制方法:将二甲亚砜减压蒸馏后,加入氧化铝放置一夜,用高50cm,填有陶制鞍形填料的蒸馏塔,于266.6~399.9Pa、50℃进行减压蒸馏,收集中间馏分。或将二甲亚砜与CaH2一起加热一日,减压蒸馏后用分子筛干燥,在氮气流下再进行减压蒸馏。也可以分步结晶精制。

5.将二甲硫醚 ( 由硫酸二甲酯与硫化钠反应制得)与二氧化氮( 由硫酸与亚硝酸钠反应制得)在60~80℃进行气液相氧化反应制得二甲基亚砜粗品,然后减压蒸馏、采用分子筛脱水后再减压精馏,即得成品二甲基亚砜。主要反应式为:

6.以丙酮作为缓冲介质,加入相等物质量的二甲硫醚和双氧水,搅拌反应,维持温度20℃:

反应结束后,直接减压蒸馏即可得纯度较高的二甲基亚砜。

用途简介

二甲基亚砜广泛用作溶剂和反应试剂,具有很高的选择性抽提能力,可用作烷烃与芳香烃分离的提取溶剂,用于芳烃、丁二烯抽提,特别是在丙烯腈聚合反应中作加工溶剂和抽丝溶剂,作聚氨酯合成及抽丝溶剂,作聚酰胺、氟氯苯胺、聚酰亚胺和聚砜树脂的合成溶剂。在医药工业中二甲基亚砜还可直接作为某些药物的原料及载体,另外,dmso本身有消炎止痛、利尿、镇静等作用,被誉为“万灵药”,常作为止痛药物的活性组分添加于药物中。也可作电容介质、防冻剂、刹车油、稀有金属提取剂等。

用途

1.可作有机溶剂;反应介质及有机合成中间体。用途极广。本品具有很高的选择性抽提能力,用作丙烯酸树脂及聚砜树酯的聚合和缩合溶剂;聚丙烯腈及乙酸纤维的聚合抽丝溶剂;烷烃与芳烃分离的抽提溶剂;用于芳烃;丁二烯抽提,腈纶纺丝;塑料溶剂及有机合成染料;制药等工业的反应介质。在医药方面,二甲基亚砜有消炎止痛作用,对皮肤有强渗透力,因而可溶解某些药物,使这类药物向人体渗透从而达到治疗目的。利用二甲基亚砜的这种载体特性,也可作为农药的添加剂。在某些农药中添加少量二甲基亚砜,有助于农药向植物内渗透,以提高药效。二甲基亚砜还可作为合成纤维的染色溶剂;去染剂;染色载体,也可作为回收乙炔;二氧化硫的吸收剂,合成纤维改性剂,防冻剂以及电容介质;刹车油;稀有金属提取剂等。

2.二甲基亚砜是一种既溶于水又溶于有机溶剂的极为重要的非质子极性溶剂。广泛用作溶剂和反应试剂,具有很高的选择抽提能力。可用作烷烃与芳香烃分离的提取溶剂;用作聚酰胺、氟氯苯胺、
聚酰亚胺和聚砜树脂的合成溶剂;也用作乙炔、芳烃、二氧化硫及其他气体的溶剂。DMSO有消炎止痛、利尿、镇静等作用,在医药工业中二甲基亚砜还可直接作为某些药物的原料及载体,对皮肤有极强的渗透性,有助于药物向人体渗透。还可用作电容介质、防冻剂、刹车油、稀有金属提取剂等。

3. 用作分析试剂,如作电化学分析的溶剂、高温溶剂及气相色谱固定液。还用作反应介质。

二甲亚砜 物化性质

外观与性状:
无色液体
密度:
1.100 g/mL at 20 °C
熔点:
18.4 °C
沸点:
189 °C(lit.)
闪点:
192 °F
折射率:
n20/D 1.479(lit.)
蒸汽密度:
2.7 (vs air)
存储条件/存储方法:

1.本品应密封于阴凉干燥处避光保存。

2.本品采用铝桶、塑料桶或玻璃瓶包装。贮存于阴凉通风干燥处,按易燃有毒物品规定贮运。

稳定性相关:

1.无色液体,可燃,几乎无臭,带有苦味。该品是极性高的有机溶剂,可与水以任意比例混合,除石油醚外,可溶解一般有机溶剂。在20℃时能吸收氯化氢30%(重量);二氧化氮30%(重量);二氧化硫65%(重量)。有强烈吸湿性,在20℃,当相对湿度为60%时,可从空气吸收相当于自身重量70%的水分。该品是弱氧化剂,不含水的二甲基亚砜对金属无腐蚀性。含水时对铁;铜等金属有腐蚀性,但对铝不腐蚀。对碱稳定。在酸存在时加热会产生少量的甲基硫醇;甲醛;二甲基硫;甲磺酸等化合物。在高温下有分解现象,遇氯能发生激烈反应,在空气中燃烧发出淡蓝色火焰。

化学性质:二甲亚砜还原生成甲硫醚。受强氧化剂作用氧化成二甲砜;

2.二甲亚砜与酰氯类物质如氰尿酰氯、苯酰氯、乙酰氯、苯碘酰氯、亚硫酰氯、硫酰氯、三氯化磷等接触时,发生激烈的放热分解反应。与硝酸结合,生成(CH3)2SO·NHO3。与碳酸钡作用可使二甲亚砜再生。与浓氢碘酸作用,生成二甲硫磺化合物。

3.二甲亚砜有吸水性,用前需要进行干燥处理。

其它信息:

1.       性状:无色黏稠透明油状液体或结晶体。具弱碱性,几乎无臭,稍带苦味。

2.       密度(g/mL,20/4℃):1.100

3.       相对蒸汽密度(g/mL,空气=1):2.7

4.       熔点(ºC):18.45

5.       沸点(ºC,常压):189

6.       折射率(25ºC):1.4795

7.       黏度(mPa·s,25ºC):1.1

8.       闪点(ºC,开口):95

9.       燃点(ºC):300~302

10.    蒸发热(KJ/mol,25ºC):52.92

11.    熔化热(KJ/mol):13.94

12.    生成热(KJ/mol):-197.66

13.    燃烧热(KJ/mol,定容):1793.16

14.    比热容(KJ/(kg·K),25ºC,定压):1.95

15.    电导率(S/m,20ºC):3×10-8

16.    蒸气压(kPa,20ºC):0.049

17.    蒸气压(kPa,30ºC):0.101

18.    蒸气压(kPa,47.4ºC):0.376

19.    蒸气压(kPa,56.6ºC):0.681

20.    爆炸下限(%,V/V):2.6

21.    爆炸上限(%,V/V):28.5

22.    体膨胀系数(K-1):0.00088

23.    溶解性:可与水以任意比例混合,除石油醚外,可溶解一般有机溶剂。在20℃时能吸收氯化氢30%(重量)、二氧化氮30%(重量)、二氧化硫65%(重量),不溶于除乙炔外的脂肪烃化合物。对多种化合物有溶解能力。溶于水、乙二醇、丙酮、乙醚、苯、烃类氯化物、乙二醇的酯等。

二甲亚砜 安全信息

海关代码:
29309070
WGK_Germany:
1
德国有关水污染物质的分类清单
危险类别码:
R36/37/38
安全说明:
S24/25-S37/39-S26
RTECS号:
PV6210000
危险标志:
Xi:Irritant

二甲亚砜 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PV6210000
CHEMICAL NAME :
Methyl sulfoxide
CAS REGISTRY NUMBER :
67-68-5
LAST UPDATED :
199710
DATA ITEMS CITED :
86
MOLECULAR FORMULA :
C2-H6-O-S
MOLECULAR WEIGHT :
78.14
WISWESSER LINE NOTATION :
OS1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
606 mg/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Liver - jaundice, other or unclassified
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - hemorrhage Sense Organs and Special Senses (Eye) - conjunctive irritation
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
40 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
12 gm/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5360 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7920 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
14 gm/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - hematuria
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3100 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - hemorrhage Sense Organs and Special Senses (Eye) - conjunctive irritation
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Cardiac - other changes Kidney, Ureter, Bladder - hematuria Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>11 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>5500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
12 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
21400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1070 gm/kg/13W-I
TOXIC EFFECTS :
Blood - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
192 gm/kg/4W-I
TOXIC EFFECTS :
Blood - normocytic anemia Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
6570 mL/kg/2Y-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Blood - changes in erythrocyte (RBC) count Biochemical - Metabolism (Intermediary) - other proteins
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
389 gm/kg/17W-C
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - changes in refraction Sense Organs and Special Senses (Eye) - effect, not otherwise specified
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
57600 mg/kg/4W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - hematuria Blood - normocytic anemia Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
4864 gm/kg/78W-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Ocular
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
250 ug/kg/30D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
4698 mL/kg/58W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - changes in refraction Behavioral - fluid intake
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
59 gm/kg/81W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
220 gm/kg/82W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
65340 mg/kg/66W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
66 gm/kg/66W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
56 gm/kg
SEX/DURATION :
female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
6600 mg/kg
SEX/DURATION :
female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
30750 mg/kg
SEX/DURATION :
female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
16 mg/kg
SEX/DURATION :
female 5-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
210 gm/kg
SEX/DURATION :
female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
5500 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
8250 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
240 gm/kg
SEX/DURATION :
female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
11 gm/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
5500 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
4400 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
2500 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
2500 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
DNA damage

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
1 pph
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,109,1977 *** REVIEWS *** TOXICOLOGY REVIEW ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 243,98,1975 TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 1(1),93,1971 TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,1553,1967 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 20 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 50 ppm (160 mg/m3);Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80564 No. of Facilities: 476 (estimated) No. of Industries: 11 No. of Occupations: 25 No. of Employees: 22461 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80564 No. of Facilities: 3507 (estimated) No. of Industries: 29 No. of Occupations: 40 No. of Employees: 44947 (estimated) No. of Female Employees: 16837 (estimated)
毒理学数据:

属微毒类,大鼠经口LD50为18g/kg。但对人体皮肤有渗透性,对眼有刺激作用。

二甲亚砜 分子结构与计算化学数据

分子结构数据

1、   摩尔折射率:20.17

2、   摩尔体积(cm3/mol):71.0

3、   等张比容(90.2K):182.6

4、   表面张力(dyne/cm):43.6

5、   极化率(10-24cm3):7.99

计算化学数据

1.疏水参数计算参考值(XlogP):-0.6

2.氢键供体数量:0

3.氢键受体数量:2

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积36.3

7.重原子数量:4

8.表面电荷:0

9.复杂度:29

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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