二甘醇单乙醚

外观与性状：

无色液体

密度：

0.999 g/mL at 25 °C(lit.)

熔点：

-80 °C

沸点：

202 °C(lit.)

闪点：

205 °F

水溶解性：

Miscible

折射率：

n20/D 1.427(lit.)

蒸汽压：

0.000386mmHg at 25°C

蒸汽密度：

4.63 (vs air)

存储条件/存储方法：

包装完整、轻装轻卸,库房通风、远离明火、高温、与氧化剂分开存放

稳定性相关：

1.避免与强氧化剂、强酸、酰基氯、酸酐接触。
无色液体，具有芳香气味。能与水、醇、酮、醚、四氯化碳、芳烃、脂肪烃混溶。具有吸湿性。本品毒性较低。具有醇、醚的化学性质。

2.　对中枢神经系统有抑制作用。大鼠经口LD508690mg/kg。避免长期接触皮肤。操作人员应戴防毒口罩，避免长期大量吸入。
　

其它信息：

1.     性状：无色液体。稍带愉快气味，微黏。

2.     密度（g/mL,20/4ºC）：0.9881 

3.     密度（g/mL,25/4ºC）：0.9855

4.     相对蒸汽密度（g/mL,空气=1）：4.62

5.     熔点（ºC）：-78

6.     沸点（ºC,常压）：195

7.     折射率（20ºC）：1.4300

8.     折射率（25ºC）：1.4273

9.     折射率（40ºC）：1.4194

10.    黏度（mPa·s,20ºC）：3.85

11.   黏度（mPa·s,25ºC）：3.71

12.   黏度（mPa·s,60ºC）：1.72

13.   闪点（ºC,闭口）：94

14.   闪点（ºC,开口）：96

15.   蒸发热（KJ/mol,b.p.）：47.48

16.  比热容（KJ/(kg·K),25ºC,定压）：2.25

17.  电导率（S/m,25ºC）：2.5×10^-8

18.  蒸气压（kPa,25ºC）：0.017

19.  体膨胀系数（K^-1,10~30ºC）：0.00082

20.  溶解性：能与水、甲醇、丙酮、乙醚、四氯化碳、苯等混溶。25℃时在庚烷中溶解2%。溶解油脂、树脂、染料、硝酸纤维素、聚乙酸乙烯酯等。醋酸纤维素则不溶解。

21.  临界温度（ºC）：396.85

22.  临界压力（MPa）：3.167

23.  偏心因子：0.901

24.  液相标准热熔(J·mol^-1·K^-1)：307.8

海关代码：

29094400

WGK_Germany：

1
德国有关水污染物质的分类清单

危险类别码：

R20;R36

安全说明：

S23-S24/25-S39-S26

RTECS号：

KK8750000

安全标志：

S23:不要吸入蒸汽。
S24/25:防止皮肤和眼睛接触。
S39:佩戴眼/面防护装置。
S36:穿戴合适的防护服装。
S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。

危险标志：

Xn:Harmful

CHEMICAL IDENTIFICATION

RTECS NUMBER :

KK8750000

CHEMICAL NAME :

Ethanol, 2-(2-ethoxyethoxy)-

CAS REGISTRY NUMBER :

111-90-0

BEILSTEIN REFERENCE NO. :

1736441

LAST UPDATED :

199712

DATA ITEMS CITED :

42

MOLECULAR FORMULA :

C6-H14-O3

MOLECULAR WEIGHT :

134.20

WISWESSER LINE NOTATION :

Q2O2O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5500 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - coma

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

6 gm/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - coma

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

360 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

6 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

4 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

7500 mg/kg

TOXIC EFFECTS :

Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - excitement

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

6600 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - coma

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

6 gm/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - coma

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2300 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - ptosis Lungs, Thorax, or Respiration - cyanosis Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

5500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

7150 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

3 gm/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - coma

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

1 gm/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex)

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

3620 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

4200 uL/kg

TOXIC EFFECTS :

Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

2500 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - coma

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

3670 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

>32 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

3 gm/kg

TOXIC EFFECTS :

Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - excitement

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

692 gm/kg/2Y-C

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in spleen Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

225 gm/kg/90D-C

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

158 gm/kg/6W-I

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - hematuria Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5 mg/m3/24H/17W-C

TOXIC EFFECTS :

Brain and Coverings - recordings from specific areas of CNS Blood - other changes

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1365 mg/kg/26W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

583 gm/kg/90D-I

TOXIC EFFECTS :

Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

26700 uL/kg/30D-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - other changes Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - pig

DOSE/DURATION :

100 gm/kg/90D-I

TOXIC EFFECTS :

Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

44 gm/kg

SEX/DURATION :

female 7-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

32 gm/kg

SEX/DURATION :

female 6-13 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

246 gm/kg

SEX/DURATION :

multigeneration

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - other postnatal measures or effects

MUTATION DATA

TYPE OF TEST :

Mutation in microorganisms

TEST SYSTEM :

Bacteria - Salmonella typhimurium

DOSE/DURATION :

986 mg/plate

REFERENCE :

BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 125,401,1986 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(5),223,1985 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83102 No. of Facilities: 38144 (estimated) No. of Industries: 218 No. of Occupations: 126 No. of Employees: 352049 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83102 No. of Facilities: 36712 (estimated) No. of Industries: 204 No. of Occupations: 133 No. of Employees: 576488 (estimated) No. of Female Employees: 222885 (estimated)

毒理学数据：

1、急性数据：LD50：5540mg/kg(大鼠经口)；6580mg/kg(小鼠经口)

2、刺激数据：皮肤-兔500毫克/24小时轻度;眼睛-兔 125毫克 轻度。

3、食入过量时，会发生严重的中枢神经系统抑制及呼吸系统损害，干渴及酸毒症，尿中含有白蛋白。可引起恶心，呕吐，腹泻，头痛，腰腹痛，瞬时性的多尿症，随后少尿，可以引起肾衰竭。

生态数据：

对水有稍微的危害。

分子结构数据

1、  摩尔折射率：34.87

2、  摩尔体积（cm³/mol）：137.8

3、  等张比容（90.2K）：326.9

4、  表面张力（dyne/cm）：31.6

5、  极化率（10^-24cm³）：13.82

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:1

3.氢键受体数量:3

4.可旋转化学键数量:6

5.互变异构体数量:无

6.拓扑分子极性表面积38.7

7.重原子数量:9

8.表面电荷:0

9.复杂度:47.6

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

• 
  二甘醇乙醚红外图谱(IR1)
• 
  二甘醇乙醚红外图谱(IR2)
• 
  二甘醇乙醚质谱(MS)
• 
  二甘醇乙醚核磁图(¹³CNMR)
• 
  二甘醇乙醚Raman光谱
• 
  二甘醇乙醚核磁图(¹HNMR)