L-抗坏血酸

外观与性状：

白色至非常淡黄色结晶粉末

密度：

1,65 g/cm3

熔点：

190-194 °C (dec.)

沸点：

415.8ºC at 760 mmHg

闪点：

180.4ºC

水溶解性：

333 g/L (20 ºC)

折射率：

21 ° (C=10, H2O)

存储条件/存储方法：

通风低温干燥

稳定性相关：

1.在干燥空气中比较稳定，不纯和许多天然产品，能被空气和光线氧化，其水溶液不稳定，很快氧化成脱氢抗坏血酸，尤其是在中性或碱性溶液中很快被氧化，遇光、热、铁和铜等金属离子均会加速氧化，能形成稳定的金属盐。为相对强的还原剂，贮存日久色变深，成不同程度的浅黄色。半数致死量（小鼠,静脉）LC50:518mg/kg.

2.遇空气和加热都易引起变质， 在碱性溶液中易于氧化而失效。在空气条件下， 在水溶液中迅速变质， 是强还原剂.

3. 存在于烟气中。

4. 广泛分布于动植物体内。干燥时对空气稳定。水溶液迅速被空气氧化。

其它信息：

1.      性状： 通常是片状，有时是针状的单斜晶体。

海关代码：

29362700

WGK_Germany：

1
德国有关水污染物质的分类清单

危险类别码：

R20/21/22

安全说明：

S24/25

RTECS号：

CI7650000

安全标志：

S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
S36:穿戴合适的防护服装。
S24/25:防止皮肤和眼睛接触。

危险标志：

Xn

CHEMICAL IDENTIFICATION

RTECS NUMBER :

CI7650000

CHEMICAL NAME :

L-Ascorbic acid

CAS REGISTRY NUMBER :

50-81-7

LAST UPDATED :

199707

DATA ITEMS CITED :

46

MOLECULAR FORMULA :

C6-H8-O6

MOLECULAR WEIGHT :

176.14

WISWESSER LINE NOTATION :

T5OV EHJ CQ DQ EYQ1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

2300 mg/kg/2D

TOXIC EFFECTS :

Blood - oxidant related (GPD deficient) anemia

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

900 mg/kg

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

11900 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>10 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>4 gm/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

3367 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

643 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

518 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

546 gm/kg/13W-I

TOXIC EFFECTS :

Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

2500 mg/kg

SEX/DURATION :

female 1-22 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

6680 mg/kg

SEX/DURATION :

female 11 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

DOSE :

800 mg/kg

SEX/DURATION :

female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

19500 mg/kg

SEX/DURATION :

female 30-58 day(s) after conception lactating female 10 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - biochemical and metabolic

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

5800 mg/kg

SEX/DURATION :

female 1-58 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

2471 mg/kg

SEX/DURATION :

multigenerations

TOXIC EFFECTS :

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :

Sperm Morphology

TYPE OF TEST :

Micronucleus test

TYPE OF TEST :

Cytogenetic analysis

TYPE OF TEST :

Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :

DNA damage

TEST SYSTEM :

Mammal - species unspecified Lymphocyte

DOSE/DURATION :

500 umol/L

REFERENCE :

JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.19- 1973- Volume(issue)/page/year: 24,263,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0462 No. of Facilities: 5030 (estimated) No. of Industries: 24 No. of Occupations: 33 No. of Employees: 69440 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0462 No. of Facilities: 7888 (estimated) No. of Industries: 41 No. of Occupations: 56 No. of Employees: 137698 (estimated) No. of Female Employees: 84231 (estimated)

毒理学数据：

1、   急性毒性：LD50：5000mg/Kg（大白鼠经口）

分子结构数据

1、   摩尔折射率：35.26

2、   摩尔体积（cm³/mol）：90.1

3、   等张比容（90.2K）：310.3

4、   表面张力（dyne/cm）：140.5

5、   介电常数（F/m）：

6、   偶极距（D）：

7、   极化率（10^-24cm³）：13.97

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:4

3.氢键受体数量:6

4.可旋转化学键数量:2

5.互变异构体数量:8

6.拓扑分子极性表面积107

7.重原子数量:12

8.表面电荷:0

9.复杂度:232

10.同位素原子数量:0

11.确定原子立构中心数量:2

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

• 
  L(+)-抗坏血酸红外图谱(IR1)
• 
  L(+)-抗坏血酸红外图谱(IR2)
• 
  L(+)-抗坏血酸质谱(MS)
• 
  L(+)-抗坏血酸核磁图(¹³CNMR)
• 
  L(+)-抗坏血酸核磁图(¹HNMR)