吗啉

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 海关数据
  • 结构与计算化学
  • 上游产品
  • 下游产品
  • 表征图谱

吗啉 基本信息

中文名称:
吗啉 
中文别名:
吗啉;
对氧氮六环;
1,4-氧氮六环;
吗啡啉;
四氢-1,4-噁嗪;
1,4-氧氮杂环己烷;
对氧氮苯烷;
四氢-1,4-恶嗪 
英文名称:
Morpholine
英文别名:
morpholine;
MORPHOLINE,ACS;
Tetrahydro-1,4-oxazine;
1,4-Oxazinan;
BASF 238;
Morpholine;
1-Oxa-4-azacyclohexane;
tetrahydro-1,4-oxazine;
perhydro-1,4-oxazine;
dihydro-1,4-oxazine;
MORPHOLIN;
Drewamine 
CAS No.:
110-91-8
分 子 式:

C4H9NO

分 子 量:
87.12
精确分子量:
87.06840
PSA:
21.26000
MDL:
MFCD00005972
EINECS:
203-815-1
BRN:
102549
InChI:
The Key: YNAVUWVOSKDBBP-UHFFFAOYSA-N
危险品标志:


CorrosiveC

风险术语:

R10;R20/21/22;R34

安全术语:

S23;S36;S45

分子结构式:
SDS:
查看

吗啉 制备方法及用途

制备方法

1.由二乙醇胺经硫酸脱水环合而得。将二乙醇胺加入水反应锅内,在60℃以下滴加硫酸,加毕,升温于185-195℃,保温30min。冷至60℃以下,滴加氢氧化钠液至pH=11,冷却,过滤,滤液精馏,收集130℃以下馏分,精吗啉含量可达99.5%以上。该法原料易得,目前已成为世界生产吗啉的主要方法。由二噁烷与氨气相催化反应而可制得吗啉。 2.由二乙醇胺在硫酸存在下脱水环合而制得。将二乙醇胺加入反应锅内,在60℃以下滴加H2SO4,加毕升温至185~195℃,保温30min,冷却至60℃,滴加NaOH溶液,使pH=11,冷却过滤,滤液精馏,收集130℃以下馏分即为吗啉。也可用二乙二醇和氨在催化剂存在和压力下制得吗啉。该方法原料易得,成为目前世界上生产吗啉的主要方法。精制方法:将吗啉与金属钠一起回流1小时,在干燥氮气流下常压蒸馏精制。或用无水硫酸钙干燥后分馏。也可以将吗啉制成草酸盐,用60%%乙醇重结晶2次,加入浓氢氧化钾水溶液使吗啉游离出来,分离后用固体氢氧化钾干燥,再用金属钠干燥,然后分馏。3.由二甘醇与氨在氢气和镍催化剂存在下于30~40MPa大气压和150~400℃温度下反应制得。或者由二乙醇胺与过量的浓盐酸(或浓硫酸)作用制得。4.在酸性环境下使二乙醇胺闭环就能制成吗啉,然后通过精馏提纯。

合成制备方法

1.由二乙醇胺经硫酸脱水环合而得。将二乙醇胺加入水反应锅内,在60℃以下滴加硫酸,加毕,升温于185-195℃,保温30min。冷至60℃以下,滴加氢氧化钠液至pH=11,冷却,过滤,滤液精馏,收集130℃以下馏分,精吗啉含量可达99.5%以上。该法原料易得,目前已成为世界生产吗啉的主要方法。由二噁烷与氨气相催化反应而可制得吗啉。

2.由二乙醇胺在硫酸存在下脱水环合而制得。将二乙醇胺加入反应锅内,在60℃以下滴加H2SO4,加毕升温至185~195℃,保温30min,冷却至60℃,滴加NaOH溶液,使pH=11,冷却过滤,滤液精馏,收集130℃以下馏分即为吗啉。
也可用二乙二醇和氨在催化剂存在和压力下制得吗啉。该方法原料易得,成为目前世界上生产吗啉的主要方法。

精制方法:将吗啉与金属钠一起回流1小时,在干燥氮气流下常压蒸馏精制。或用无水硫酸钙干燥后分馏。也可以将吗啉制成草酸盐,用60%%乙醇重结晶2次,加入浓氢氧化钾水溶液使吗啉游离出来,分离后用固体氢氧化钾干燥,再用金属钠干燥,然后分馏。

3.由二甘醇与氨在氢气和镍催化剂存在下于30~40MPa大气压和150~400℃温度下反应制得。或者由二乙醇胺与过量的浓盐酸(或浓硫酸)作用制得。

4.在酸性环境下使二乙醇胺闭环就能制成吗啉,然后通过精馏提纯。

用途简介

用作分析试剂,及树脂、蜡类、虫胶等的溶剂。广泛用作树脂、染料、蜡、虫胶、酪朊等的溶剂,锅炉防腐剂和橡胶硫化促进剂。也用于制备表面活性剂、增塑剂、抗氧剂和医药等。用作水处理缓蚀剂,由于其水溶液呈碱性,可以中和水中的游离二氧化碳提高锅炉给水ph值,减缓二氧化碳的腐蚀。可防止锅炉给水的高温酸性氧化物的腐蚀。医药方面用于合成病毒灵、布洛芬、萘谱里甲氧氯普胺、氟联苯丙酸以及咳必定、甲灭酸等多种重要药物。有机合成方面可用作N-甲基吗啉、N-乙基吗啉、吗啉脂肪酸盐等的中间体和原料。该试剂可以作为碱,可以用来合成烯胺和作为Mannich缩合反应时的催化剂。Willgerodt反应吗啡啉可用来作为Kindler改进的Willgerodt反应中的胺组分,在微波照射下,也能发生这种重排反应 (式1,式2)。亚胺的形成吗啡啉是合成烯胺的三个主要二级胺中的一个,碱性比哌啶和四氢吡咯弱,因此烯胺的形成速度要比哌啶和四氢吡咯慢。吗啡啉在形成烯胺的过程中,区域选择性也比吡啶和四氢吡咯差。饱和的醛、酮与吗啡啉合成烯胺时,可以直接在苯中加热反应,或用对甲苯磺酸、四氯化钛催化 (式3),也可用微波照射,或者与三氟磺酸烯醇酯在Pd催化作用下反应生成 (式4)。吗啡烯胺的应用虽然吗啡啉合成烯胺时的活性不高,但在合成吡咯烷酮衍生物时,产率较高。典型的例子是环戊烯吗啡啉烯胺的酰基化 (式5)。与乙酰化咪唑作用也可以使吗啡啉烯胺形成酰胺,酸化后得到酸 (式6)。用作分析试剂,及树脂、蜡类、虫胶等的溶剂。

用途

1.用作分析试剂,及树脂、蜡类、虫胶等的溶剂。广泛用作树脂、染料、蜡、虫胶、酪朊等的溶剂,锅炉防腐剂和橡胶硫化促进剂。也用于制备表面活性剂、增塑剂、抗氧剂和医药等。

2.用作水处理缓蚀剂,由于其水溶液呈碱性,可以中和水中的游离二氧化碳提高锅炉给水ph值,减缓二氧化碳的腐蚀。可防止锅炉给水的高温酸性氧化物的腐蚀。

3.医药方面用于合成病毒灵、布洛芬、萘谱里甲氧氯普胺、氟联苯丙酸以及咳必定、甲灭酸等多种重要药物。有机合成方面可用作N-甲基吗啉、N-乙基吗啉、吗啉脂肪酸盐等的中间体和原料。

4.该试剂可以作为碱,可以用来合成烯胺和作为Mannich缩合反应时的催化剂。

Willgerodt反应 吗啡啉可用来作为Kindler改进的Willgerodt反应中的胺组分[2],在微波照射下,也能发生这种重排反应(式1,式2)[3]

亚胺的形成 吗啡啉是合成烯胺的三个主要二级胺中的一个,碱性比哌啶和四氢吡咯弱,因此烯胺的形成速度要比哌啶和四氢吡咯慢。吗啡啉在形成烯胺的过程中,区域选择性也比吡啶和四氢吡咯差[4]。饱和的醛、酮与吗啡啉合成烯胺时,可以直接在苯中加热反应[5],或用对甲苯磺酸、四氯化钛催化(式3)[6],也可用微波照射[7],或者与三氟磺酸烯醇酯在Pd催化作用下反应生成(式4)[8]

吗啡烯胺的应用 虽然吗啡啉合成烯胺时的活性不高,但在合成吡咯烷酮衍生物时,产率较高。典型的例子是环戊烯吗啡啉烯胺的酰基化(式5)[9]。与乙酰化咪唑作用也可以使吗啡啉烯胺形成酰胺,酸化后得到酸(式6)[10]

5.用作分析试剂,及树脂、蜡类、虫胶等的溶剂。[34]

吗啉 物化性质

外观与性状:
无色油状液体,有氨味。
密度:
1.000 g/mL at 20 °C
熔点:
-5 °C
沸点:
129 °C(lit.)
闪点:
96 °F
水溶解性:
MISCIBLE
折射率:
n20/D 1.454(lit.)
蒸汽压:
10.4mmHg at 25°C
蒸汽密度:
3 (vs air)
存储条件/存储方法:
Store at R.T.
稳定性相关:

1.化学性质:具有仲胺的性质,碱性介于哌啶与哌嗪之间(pKa 8.36,25℃)。与脂肪酸、酸酐、酰氯反应,生成酰胺。与烷基化试剂如氯代烷、硫酸二烷基酯、甲酸与醛的混合物等反应,生成N-烷基取代物。与酮反应生成烯胺。与氯或次氯酸钠反应生成N-氯代吗啉。在干燥的乙醚中与二氧化碳作用,得到氨基甲酸衍生物。在酸性高锰酸钾溶液中逐渐发生氧化作用。

2.蒸气刺激皮肤及眼黏膜,引起呼吸困难,具有全身毒性作用,可引起肝、肾变性及坏死性病变。人体在43mg/L浓度下,作用1min,对鼻黏膜产生强烈的刺激,作用1.5min,出现咳嗽。在倾倒未稀释的本品时,吸入其蒸气者,咽喉即发生剧烈疼痛,咽部黏膜剧烈充血。未稀释的吗啉附在皮肤上可引起难以忍受的疼痛,并能透过皮肤吸收。空气中最高容许浓度0.5mg/m3。生产车间要求通风良好,设备要密闭。操作人员要十分注意保护眼睛及皮肤,戴密闭眼镜、手套等。当接触高浓度时,要使用过滤式工业防护面具(A型)。应限制溶液中游离碱的含量不得超过2%。

3.稳定性[30]  稳定

4.禁配物[31]  酸类、酰基氯、酸酐、强氧化剂

5.聚合危害[32]  不聚合

其它信息:

1.性状:无色油状吸湿性液体,有氨味。[11]

2.熔点(℃):-5[12]

3.沸点(℃):128.9[13]

4.相对密度(水=1):1.00[14]

5.相对蒸气密度(空气=1):3.0[15]

6.饱和蒸气压(kPa):1.06(20℃)[16]

7.临界温度(℃):344[17]

8.临界压力(MPa):5.302[18]

9.辛醇/水分配系数:-0.86[19]

10.闪点(℃):38(OC)[20]

11.引燃温度(℃):310[21]

12.爆炸上限(%):11.2[22]

13.爆炸下限(%):1.4[23]

14.溶解性:与水混溶,可混溶于多数有机溶剂。[24]

15.黏度(mPa·s,15ºC):2.5334

16.黏度(mPa·s,20ºC):2.33

17.蒸发热(KJ/mol):43.96

18.熔化热(KJ/mol):14.53

吗啉 安全信息

包装等级:
I
风险类别:
8
海关代码:
2934999090
WGK_Germany:
3
德国有关水污染物质的分类清单
危险类别码:
R10;R20/21/22;R34
安全说明:
S23-S36-S45
RTECS号:
QD6475000
安全标志:
S23:不要吸入蒸汽。
S36:穿戴合适的防护服装。
S45:出现意外或者感到不适,立刻到医生那里寻求帮助(最好带去产品容器标签)。
危险标志:
C:Corrosive

吗啉 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QD6475000
CHEMICAL NAME :
Morpholine
CAS REGISTRY NUMBER :
110-91-8
BEILSTEIN REFERENCE NO. :
0102549
LAST UPDATED :
199712
DATA ITEMS CITED :
57
MOLECULAR FORMULA :
C4-H9-N-O
MOLECULAR WEIGHT :
87.14
WISWESSER LINE NOTATION :
T6M DOTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8000 ppm/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
525 mg/kg
TOXIC EFFECTS :
Behavioral - sleep Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1320 mg/m3/2H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
413 mg/kg
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
458 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
500 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
1220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
12000 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
24 gm/kg/30D-I
TOXIC EFFECTS :
Gastrointestinal - necrotic changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
70 mg/m3/4H/17W-I
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section Blood - changes in leukocyte (WBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 ppm/6H/13W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
9 gm/kg/10D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration Skin and Appendages - primary irritation (after topical exposure) Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
13500 mg/kg/30D-I
TOXIC EFFECTS :
Gastrointestinal - necrotic changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
70 mg/m3/4H/17W-I
TOXIC EFFECTS :
Liver - liver function tests impaired Kidney, Ureter, Bladder - other changes in urine composition
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
27 gm/kg/30D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in both tubules and glomeruli Skin and Appendages - primary irritation (after topical exposure) Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2560 mg/kg/Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - bronchiogenic carcinoma Liver - tumors

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0779-0294 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 71 mg/m3 (20 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 47,199,1989 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 47,199,1989 TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 8,707,1989 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 20 ppm (70 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,175,1971 OSHA PEL (Gen Indu):8H TWA 20 ppm (70 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 20 ppm (70 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 20 ppm (70 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 20 ppm (70 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 20 ppm (70 mg/m3);STEL 30 ppm (105 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 20 ppm (71 mg/m3);STEL 30 ppm (107 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 20 ppm (70 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 20 ppm (70 mg/m3);STEL 30 ppm (105 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 20 ppm (70 mg/m3);STEL 30 ppm (105 mg/m3) JAN 1993 OEL-GERMANY:TWA 20 ppm (70 mg/m3);Skin JAN 1993 OEL-HUNGARY:STEL 10 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 20 ppm (70 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 20 ppm (70 mg/m3);Skin JAN 1993 OEL-RUSSIA:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 20 ppm (70 mg/m3);STEL 30 ppm (110 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 20 ppm (70 mg/m3);STEL 40 ppm;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 20 ppm (70 mg/m3);STEL 30 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MORPHOLINE-air:10H TWA 20 ppm (Sk);STEL 30 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 48910 No. of Facilities: 20431 (estimated) No. of Industries: 132 No. of Occupations: 82 No. of Employees: 122734 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 48910 No. of Facilities: 13767 (estimated) No. of Industries: 133 No. of Occupations: 105 No. of Employees: 214367 (estimated) No. of Female Employees: 65146 (estimated)
毒理学数据:

1.急性毒性[25]

LD50:1450mg/kg(大鼠经口);525mg/kg(小鼠经口);500μl(500mg)/kg(兔经皮)

LC50:8000ppm(大鼠吸入,8h)

2.刺激性[26]

家兔经皮:995mg(24h),重度刺激。

家兔经眼:2mg,重度刺激。

3.亚急性与慢性毒性[27] 大鼠吸入6.4g/m3(反复吸入),眼、呼吸道刺激,肺、肝和肾有病变。

生态数据:

1.生态毒性[28]

LC50:350~400mg/L(96h)(鱼)

IC50:1.7~4.1mg/L(72h)(藻类)

2.生物降解性 暂无资料

3.非生物降解性 暂无资料

4.其他有害作用[29]  该物质对环境有危害,应特别注意对地表水、土壤、大气和饮用水的污染。

吗啉 MSDS

第一部分:化学品名称

吗啉 海关数据

中国海关编码:2934999090

概述:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素:
品名, 成分含量, 用途
摘要/Summary:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

吗啉 分子结构与计算化学数据

分子结构数据

1、摩尔折射率:23.40

2、摩尔体积(cm3/mol):93.5

3、等张比容(90.2K):217.6

4、表面张力(dyne/cm):29.2

5、极化率(10-24cm3):9.27

计算化学数据

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:1

3.氢键受体数量:2

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积21.3

7.重原子数量:6

8.表面电荷:0

9.复杂度:34.5

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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