N-乙基吗啉

外观与性状：

无色液体

密度：

0.91 g/mL at 20 °C(lit.)

熔点：

−63 °C(lit.)

沸点：

139 °C(lit.)

闪点：

82 °F

水溶解性：

miscible

折射率：

n20/D 1.441(lit.)

蒸汽压：

6.36mmHg at 25°C

存储条件/存储方法：

库房通风低温干燥,与氧化剂、酸类分开存放

稳定性相关：

1.避免与氧化物接触。本品是一种比较稳定的化合物，但容易燃烧。具有叔胺的化学性质（pKa 7.7）。

2.本品与吗啉同样能刺激皮肤及黏膜，但毒性较轻，未引起肝、肾的改变。小白鼠吸入ＬＣ５０１８ｍｇ／Ｌ。大鼠灌胃ＬＤ５０１．２ｇ／ｋｇ。根据中枢神经系统总和能力的变化，本品一次作用的阈浓度为０．０９～０．１ｍｇ／Ｌ，反复给药，浓度逐步增加，则产生习惯性。对人的刺激作用阈浓度为０．２２ｍｇ／Ｌ。对皮肤的刺激作用为吗啉的１／２０。在空气中的容许浓度为５ｍｇ／ｍ３。个人防护和预防措施参见吗啉（Ｄ０５９）。
　

其它信息：

1.      性状：无色液体

2.      相对密度（g/mL,20/20℃）：0.916

3.      密度（g/mL,20/4℃）：0.8996

4.      相对蒸汽密度（g/mL,空气=1）：4.00

5.      熔点（ºC）：-63

6.      沸点（ºC,常压）：138

7.      折射率（20ºC）：1.4400

8.      闪点（ºC）：32

9.      蒸气压（kPa）：0.813

10.    溶解性：能与水、乙醇、乙醚混溶。溶于丙酮和苯。

包装等级：

II

风险类别：

8

海关代码：

29349990

WGK_Germany：

1
德国有关水污染物质的分类清单

危险类别码：

R10;R21/22;R34

安全说明：

S26-S36/37/39-S45-S16

RTECS号：

QE4025000

安全标志：

S16:远离火源。
S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
:

危险标志：

C:Corrosive;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

QE4025000

CHEMICAL NAME :

Morpholine, 4-ethyl-

CAS REGISTRY NUMBER :

100-74-3

BEILSTEIN REFERENCE NO. :

0102969

LAST UPDATED :

199806

DATA ITEMS CITED :

31

MOLECULAR FORMULA :

C6-H13-N-O

MOLECULAR WEIGHT :

115.20

WISWESSER LINE NOTATION :

T6N DOTJ A2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Open irritation test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1780 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2000 ppm/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

18000 mg/m3/2H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

180 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

1200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :

Mutation in microorganisms

TEST SYSTEM :

Bacteria - Salmonella typhimurium

REFERENCE :

ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9(Suppl 9),1,1987 *** REVIEWS *** ACGIH TLV-TWA 24 mg/m3 (5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 20 ppm (94 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,113,1971 OSHA PEL (Gen Indu):8H TWA 20 ppm (94 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 20 ppm (94 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 20 ppm (94 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 20 ppm (94 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (23 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 5 ppm (24 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (23.5 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 20 ppm (94 mg/m3);STEL 30 ppm (140 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (23 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (23 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 20 ppm (94 mg/m3);Skin JAN 1993 OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 2 ppm (25 mg/m3);STEL 10 ppm (50 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (25 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (23 mg/m3);STEL 20 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO N-ETHYLMORPHOLINE-air:10H TWA 5 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 32840 No. of Facilities: 37 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 967 (estimated)

毒理学数据：

1、皮肤/眼睛刺激性：开始刺激试验：兔子皮肤接触，453mgREACTION SEVERITY，轻微反应；

生态数据：

该物质对水有稍微的危害。

分子结构数据

1、   摩尔折射率：32.94

2、   摩尔体积（cm³/mol）：126.1

3、   等张比容（90.2K）：287.3

4、   表面张力（dyne/cm）：26.9

5、   介电常数：

6、   偶极距（10^-24cm³）：

7、 极化率：13.06

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:2

4.可旋转化学键数量:1

5.互变异构体数量:无

6.拓扑分子极性表面积12.5

7.重原子数量:8

8.表面电荷:0

9.复杂度:59.5

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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  4-乙基吗啉质谱(MS)
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  4-乙基吗啉核磁图(¹³CNMR)
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  4-乙基吗啉核磁图(¹HNMR)
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  4-乙基吗啉红外图谱(IR1)
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