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卡美噻嗪 基本信息
- 中文名称：
- 卡美噻嗪
- 中文别名：
- 卡美噻嗪
- 英文名称：
- 2H-1,2,4-Benzothiadiazine-3-carboxylicacid, 7-(aminosulfonyl)-6-chloro-3,4-dihydro-2-methyl-, methyl ester,1,1-dioxide
- 英文别名：
- Methyl 6-chloro-2-methyl-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzoth iadiazine-3-carboxylate 1,1-dioxide;
carmetizide;
3.8-Dinitro-6-chlor-phenanthridin;
6-chloro-3,8-dinitro-phenanthridine;
6-Chlor-3,8-dinitro-phenanthridin;
6-Chlor-3.4-dihydro-3-methoxycarbonyl-2-methyl-7-sulfamoyl-2H-1.2.4-benzothiadiazin-1.1-dioxid
- CAS No.：
- 42583-55-1
- 分 子 式：
- C10H12ClN3O6S2
- 分 子 量：
- 369.82
- 精确分子量：
- 368.98600
- PSA：
- 152.63000
- InChI：
- The Key: PFRBORHNFYMVOA-UHFFFAOYSA-N
- 安全术语：
- An experimental teratogen. When heated to decomposition it emits toxic fumes of Cl−, SOx, and NOx. See also ESTERS.
- 分子结构式：
-
- SDS：
- 查看
卡美噻嗪 物化性质
- 密度：
- 1.618g/cm3
- 沸点：
- 589.4ºC at 760mmHg
- 闪点：
- 310.3ºC
- 折射率：
- 1.605
- 存储条件/存储方法：
- 库房低温通风干燥
卡美噻嗪 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DK8180000
- CHEMICAL NAME :
- 2H-1,2,4-Benzothiadiazine-3-carboxylic acid,
7-(aminosulfonyl)-6-chloro-3,4-dihydro- 2-methyl-,
methyl ester, 1,1-dioxide
- CAS REGISTRY NUMBER :
- 42583-55-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C10-H12-Cl-N3-O6-S2
- MOLECULAR WEIGHT :
- 369.82
- WISWESSER LINE NOTATION :
- T66 BSWN EM DHJ C1 DVO1 HG ISZW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,231,1973
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 6 gm/kg
- SEX/DURATION :
- female 9-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,267,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1500 mg/kg
- SEX/DURATION :
- female 9-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,267,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1500 mg/kg
- SEX/DURATION :
- female 7-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,267,1973
