氟里昂-12

外观与性状：

无色无臭气体

密度：

1.329

熔点：

-158°C

沸点：

-29.79°C

闪点：

11 °C

水溶解性：

Insoluble. 0.028 g/100 mL

折射率：

1.169

存储条件/存储方法：

库房通风低温干燥,轻装轻卸,与易燃物分开存放

稳定性相关：

1.稳定性^[17]  稳定

2.禁配物^[18]  强氧化剂、碱金属、碱土金属、铝

3.避免接触的条件^[19]  受热

4.聚合危害^[20]  不聚合

5.分解产物^[21] 氟化氢、氯化氢

其它信息：

1.性状：无色无味压缩或液化气体。^[1]

2.熔点（℃）：-158^[2]

3.沸点（℃）：-30^[3]

4.相对密度（水=1）：1.46（-30℃）^[4]

5.相对蒸气密度（空气=1）：4.2^[5]

6.饱和蒸气压（kPa）：568（20℃）^[6]

7.临界温度（℃）：111.8^[7]

8.临界压力（MPa）：4.12^[8]

9.辛醇/水分配系数：2.16^[9]

10.溶解性：不溶于水，溶于乙醇、乙醚。^[10]

11.黏度（气体，mPa·s）：12.500

12.黏度（液体，mPa·s）：0.234

13.汽化热（KJ/mol）：20.61

14.相对密度（20℃，4℃）：1.75^-115

15.临界密度（g·cm^-3）：0.561

16.临界体积（cm³·mol^-1）：213

17.临界压缩因子：0.275

18.偏心因子：0.180

19.Lennard-Jones参数（A）：7.038

20.Lennard-Jones参数（K）：187.9

21.溶度参数(J·cm^-3)^0.5：15.112

22.van der Waals面积（cm²·mol^-1）：5.940×10⁹

23.van der Waals体积（cm³·mol^-1）：39.810

24.液相标准热熔(J·mol^-1·K^-1)：121.1

25.气相标准声称热(焓)( kJ·mol^-1) ：-490.8

26.气相标准熵(J·mol^-1·K^-1) ：300.6

27.气相标准生成自由能( kJ·mol^-1)：-451.7

28.气相标准热熔(J·mol^-1·K^-1)：72.28

风险类别：

2.2

海关代码：

2903772011

危险类别码：

R20;R59

安全说明：

S23-S24/25-S59-S61-S45-S24-S16-S7-S36/37

安全标志：

S7:保持容器紧密封闭。
S16:远离火源。
S24:避免接触皮肤。
S25:避免接触眼睛。

危险标志：

Xn:Harmful;N:Dangerousfortheenvironment;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

PA8200000

CHEMICAL NAME :

Methane, dichlorodifluoro-

CAS REGISTRY NUMBER :

75-71-8

LAST UPDATED :

199712

DATA ITEMS CITED :

49

MOLECULAR FORMULA :

C-Cl2-F2

MOLECULAR WEIGHT :

120.91

WISWESSER LINE NOTATION :

GXGFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human

DOSE/DURATION :

200000 ppm/30M

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - fibrosing alveolitis Liver - other changes

REFERENCE :

EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9. Volume(issue)/page/year: 9,385,1976

TYPE OF TEST :

LD - Lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>5600 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(3),73,1987

TYPE OF TEST :

LC - Lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>80 pph/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0520424

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

3348 gm/m3/3H

TOXIC EFFECTS :

Behavioral - sleep Behavioral - tremor Behavioral - excitement

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 28(6),95,1963

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

80 pph/30M

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9. Volume(issue)/page/year: 9,385,1976

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

80 pph/30M

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9. Volume(issue)/page/year: 9,385,1976 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2548 mg/kg/26W-I

TOXIC EFFECTS :

Behavioral - alteration of classical conditioning Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(3),73,1987

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

4136 mg/m3/8H/6W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - chronic pulmonary edema Related to Chronic Data - death

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 10,270,1967

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3997 mg/m3/90D-C

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - chronic pulmonary edema Related to Chronic Data - death

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 10,270,1967

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Primate - monkey

DOSE/DURATION :

3997 mg/m3/90D-C

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - chronic pulmonary edema

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 10,270,1967

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

3997 mg/m3/90D-C

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - chronic pulmonary edema

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 10,270,1967

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

3997 mg/m3/90D-C

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 10,270,1967 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 4950 mg/m3 (1000 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 18,365,1974 TOXICOLOGY REVIEW NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of New York, POB 5405, Lake Success, NY 11042) V.1- 1901- Volume(issue)/page/year: 74,1939,1974 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 1000 ppm (4950 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,78,1971 OSHA PEL (Gen Indu):8H TWA 1000 ppm (4950 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1000 ppm (4950 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1000 ppm (4950 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1000 ppm (4950 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1000 ppm (4950 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 1000 ppm (5000 mg/m3) JAN 1993 OEL-BELGIUM:TWA 1000 ppm (4950 mg/m3) JAN 1993 OEL-DENMARK:TWA 1000 ppm (4950 mg/m3) JAN 1993 OEL-FINLAND:TWA 1000 ppm (4950 mg/m3);STEL 1250 ppm (6200 mg/m3) JAN 1993 OEL-FRANCE:TWA 1000 ppm (4950 mg/m3) JAN 1993 OEL-GERMANY:TWA 1000 ppm (5000 mg/m3) JAN 1993 OEL-HUNGARY:TWA 100 mg/m3;STEL 200 mg/m3 JAN 1993 OEL-JAPAN:TWA 500 ppm (2500 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 1000 ppm (4950 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 1000 ppm (4950 mg/m3) JAN 1993 OEL-POLAND:TWA 4000 mg/m3 JAN 1993 OEL-RUSSIA:TWA 500 ppm;STEL 3000 mg/m3 JAN 1993 OEL-SWEDEN:TWA 500 ppm (2500 mg/m3);STEL 750 ppm (4000 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 1000 ppm (5000 mg/m3) JAN 1993 OEL-TURKEY:TWA 1000 ppm (4950 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 1000 ppm (4950 mg/m3);STEL 1250 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DICHLORODIFLUOROMETHANE-air:10H TWA 1000 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 24095 No. of Facilities: 139220 (estimated) No. of Industries: 403 No. of Occupations: 213 No. of Employees: 1892483 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 24095 No. of Facilities: 30739 (estimated) No. of Industries: 177 No. of Occupations: 140 No. of Employees: 510790 (estimated) No. of Female Employees: 143439 (estimated)

毒理学数据：

1.急性毒性^[11]  LC50：800000ppm（大鼠吸入，30min）

2.刺激性 暂无资料

3.亚急性与慢性毒性^[12]  大鼠及豚鼠，吸入浓度4000mg/m³,90d以上，15只动物死亡1~2只，出现肝脂肪变化，局灶性坏死，以及肺的非特异性变化。

4.其他^[13]  TCLo：200000ppm（人吸入，30min）

生态数据：

1.生态毒性  暂无资料

2.生物降解性^[14]

好氧生物降解（h）：672~4032

厌氧生物降解（h）：2688~16128

3.非生物降解性^[15]

光解最大光吸收-高（nm）：＜200

空气中光氧化半衰期（h）：2118~21180

4.其他有害作用^[16]  该物质对环境有危害，应特别注意大气的污染，其臭氧消耗潜能ODP为1，对大气臭氧层有极强破坏力。

分子结构数据

1、摩尔折射率：16.67

2、摩尔体积（cm³/mol）：78.7

3、等张比容（90.2K）：352.5

4、表面张力（dyne/cm）：38.4

5、极化率（10-24cm3）：18.14

计算化学数据

1.疏水参数计算参考值（XlogP）:2.3

2.氢键供体数量:0

3.氢键受体数量:2

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积0

7.重原子数量:5

8.表面电荷:0

9.复杂度:30.6

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1