1,3-二氯丙烯

外观与性状：

黄色液体

密度：

1.2

熔点：

-60 °C

沸点：

97-112 °C(lit.)

闪点：

78 °F

水溶解性：

<0.01 g/100 mL at 16.5℃

折射率：

n20/D 1.472(lit.)

存储条件/存储方法：

库房通风低温干燥,与氧化剂分开存放,不宜久储,以防聚合

稳定性相关：

1.稳定性^[19]  稳定

2.禁配物^[20]  强氧化剂、酸类

3.避免接触的条件^[21]  受热

4.聚合危害^[22]  聚合

5.分解产物^[23]  氯化氢、光气

其它信息：

1.性状：琥珀色液体，有类似氯仿的气味。^[1]

2.熔点（℃）：-84^[2]

3.沸点（℃）：108^[3]

4.相对密度（水=1）：1.22^[4]

5.相对蒸气密度（空气=1）：3.8^[5]

6.饱和蒸气压（kPa）：4.5（25℃）^[6]

7.燃烧热（kJ/mol）：-1775.5^[7]

8.辛醇/水分配系数：1.82^[8]

9.闪点（℃）：25（CC）；35（OC）^[9]

10.爆炸上限（%）：14.5^[10]

11.爆炸下限（%）：5.0^[11]

12.溶解性：不溶于水，溶于乙醇、乙醚、苯等多数有机溶剂。^[12]

包装等级：

II

风险类别：

3

海关代码：

2903199000

WGK_Germany：

3
德国有关水污染物质的分类清单

危险类别码：

R10;R20/21;R25;R36/37/38;R43;R50/53

安全说明：

S36/37-S45-S60-S61

RTECS号：

UC8310000

安全标志：

S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S60:本物质残余物和容器必须作为危险废物处理。
S61:避免排放到环境中。参考专门的说明/安全数据表。
:

危险标志：

T:Toxic;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

UC8310000

CHEMICAL NAME :

Propene, 1,3-dichloro-

CAS REGISTRY NUMBER :

542-75-6

BEILSTEIN REFERENCE NO. :

1719556

LAST UPDATED :

199712

DATA ITEMS CITED :

46

MOLECULAR FORMULA :

C3-H4-Cl2

MOLECULAR WEIGHT :

110.97

WISWESSER LINE NOTATION :

G2U1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

470 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1000 ppm/2H

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - lacrimation

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

775 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

175 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

640 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

4650 mg/m3/2H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

504 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

400 ppm/7H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

455 mg/kg/26W-I

TOXIC EFFECTS :

Gastrointestinal - changes in structure or function of endocrine pancreas Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other hydrolases

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1365 mg/kg/13W-C

TOXIC EFFECTS :

Gastrointestinal - alteration in gastric secretion Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

90 ppm/6H/13W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1365 mg/kg/13W-C

TOXIC EFFECTS :

Cardiac - changes in heart weight Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

90 ppm/6H/13W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

15600 mg/kg/2Y-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

31200 mg/kg/2Y-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

60 ppm/6H/5D/2Y

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :

Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :

Sister chromatid exchange

TEST SYSTEM :

Rodent - hamster Ovary

REFERENCE :

CNJGA8 Canadian Journal of Genetics and Cytology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1959- Volume(issue)/page/year: 22,681,1980 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 4.5 mg/m3 (1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,113,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,113,1986 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,195,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1 ppm (5 mg/m3);Skin;Carcinogen JAN 1993 OEL-BELGIUM:TWA 1 ppm (4.5 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 1 ppm (5 mg/m3);Skin JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 1,3-DICHLOROPROPENE-air:8H CA TWA 1 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3912 No. of Facilities: 48 (estimated) No. of Industries: 3 No. of Occupations: 14 No. of Employees: 2162 (estimated) No. of Female Employees: 33 (estimated)

毒理学数据：

1.急性毒性^[13]

LD50：470~710mg/kg（大鼠经口）；640mg/kg（小鼠经口）；775mg/kg（大鼠经皮）；504mg/kg（兔经皮）

LC50：500ppm（大鼠吸入）；4650mg/m³（小鼠吸入，2h）

2.刺激性  暂无资料

3.亚急性与慢性毒性^[14]  大鼠吸入50ppm，每天6h，12周，肝肾肿大，动物存活。

4.致突变性^[15]  微生物致突变：鼠伤寒沙门菌100μg/皿。姐妹染色单体交换：仓鼠卵巢900nmol/L。DNA损伤：小鼠腹腔内给予150mg/kg。

5.致癌性^[16]  IARC致癌性评论：G2B，人类可疑致癌物。

生态数据：

1.生态毒性  暂无资料

2.生物降解性^[17]

好氧生物降解（h）：168~672

厌氧生物降解（h）：672~2688

3.非生物降解性^[18]

空气中光氧化半衰期（h）：4.66~80.3

一级水解半衰期（h）：271

中国海关编码：2903199000

概述：

2903199000 其他无环烃的饱和氯化衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

申报要素：

品名, 成分含量, 用途

摘要/Summary：

2903199000 other saturated chlorinated derivatives of acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

分子结构数据

1、摩尔折射率：25.70

2、摩尔体积（cm³/mol）：94.4

3、等张比容（90.2K）：215.6

4、表面张力（dyne/cm）：27.1

5、极化率（10^-24cm³）：10.18

计算化学数据

1、疏水参数计算参考值（XlogP）：1.7

2、氢键供体数量：0

3、氢键受体数量：0

4、可旋转化学键数量：1

5、互变异构体数量：

6、拓扑分子极性表面积（TPSA）：0

7、重原子数量：5

8、表面电荷：0

9、复杂度：31.9

10、同位素原子数量：0

11、确定原子立构中心数量：0

12、不确定原子立构中心数量：0

13、确定化学键立构中心数量：1

14、不确定化学键立构中心数量：0

15、共价键单元数量：1

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  3-二氯丙烯红外图谱(IR1)