一氯甲烷

外观与性状：

无色气体

密度：

0.92

熔点：

-97ºC

沸点：

-24.2ºC

闪点：

-46ºC

折射率：

1.0007

存储条件/存储方法：

库房通风低温干燥,轻装轻卸,与氧气、空气等助燃气体钢瓶分开存放

稳定性相关：

1.稳定性^[23]   稳定

2.禁配物^[24]   强氧化剂、镁、钾、钠及其合金等

3.避免接触的条件^[25]   潮湿空气

4.聚合危害^[26]   不聚合

5.分解产物^[27]   氯化氢

其它信息：

1.性状：无色气体，有醚样的微甜气味。^[1]

2.熔点（ºC）：-97.6^[2]

3.沸点（ºC）：-23.7^[3]

4.相对密度（水=1）：0.92^[4]

5.相对蒸气密度（空气=1）：1.8^[5]

6.饱和蒸气压（kPa）：506.62（22ºC）^[6]

7.燃烧热（kJ/mol）：-620.27^[7]

8.临界温度（ºC）：143.8^[8]

9.临界压力（MPa）：6.68^[9]

10.辛醇/水分配系数：0.91^[10]

11.闪点（ºC）：-46^[11]

12.引燃温度（ºC）：632^[12]

13.爆炸上限（%）：17.4^[13]

14.爆炸下限（%）：8.1^[14]

15.溶解性：微溶于水，溶于乙醇、氯仿、苯、四氯化碳、冰醋酸等。^[15]

16.临界密度（g·cm^-3）：0.363

17.临界体积（cm³·mol^-1）：139

18.临界压缩因子：0.269

19.偏心因子：0.153

20.相对密度（20℃，4℃）：0.9197⁵

21.Lennard-Jones参数（A）：4.6296

22.ennard-Jones参数（K）：228.08 

23.der Waals面积（cm²·mol^-1）：3.920×10⁹

24.der Waals体积（cm³·mol^-1）：25.290

25.气相标准声称热(焓)( kJ·mol^-1) ：-82.0

26.气相标准熵(J·mol^-1·K^-1) ：234.30

27.气相标准生成自由能( kJ·mol^-1)：-58.4

28.气相标准热熔(J·mol^-1·K^-1)：40.73

风险类别：

2.1

海关代码：

2903110000

WGK_Germany：

2
德国有关水污染物质的分类清单

危险类别码：

R12

安全说明：

9-16-33

RTECS号：

PA6300000

安全标志：

S9:保持容器在一个有良好通风放的场所。
S16:远离火源。
S33:采取防护措施防止静电发生。

CHEMICAL IDENTIFICATION

RTECS NUMBER :

PA6300000

CHEMICAL NAME :

Methane, chloro-

CAS REGISTRY NUMBER :

74-87-3

LAST UPDATED :

199806

DATA ITEMS CITED :

70

MOLECULAR FORMULA :

C-H3-Cl

MOLECULAR WEIGHT :

50.49

WISWESSER LINE NOTATION :

G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human

DOSE/DURATION :

20000 ppm/2H

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1800 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5300 mg/m3/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2200 ppm/6H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

14661 ppm/6H

TOXIC EFFECTS :

Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

129 mg/m3/4H

TOXIC EFFECTS :

Behavioral - general anesthetic Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

20000 ppm/2H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3000 ppm/6H/5D-I

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

41 mg/m3/4H/26W-I

TOXIC EFFECTS :

Liver - liver function tests impaired Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

150 ppm/22H/11D-C

TOXIC EFFECTS :

Behavioral - changes in motor activity (specific assay) Endocrine - changes in thymus weight Related to Chronic Data - death

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

500 ppm/24H/3D-C

TOXIC EFFECTS :

Brain and Coverings - other degenerative changes Behavioral - tremor Behavioral - ataxia

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

2000 ppm/6H

SEX/DURATION :

male 5 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

1500 ppm/6H

SEX/DURATION :

male 50 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

1500 ppm/6H

SEX/DURATION :

female 7-19 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

3000 ppm/6H

SEX/DURATION :

male 5 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

3000 ppm/6H

SEX/DURATION :

male 5 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

500 ppm/6H

SEX/DURATION :

female 6-17 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

750 ppm/6H

SEX/DURATION :

female 6-17 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :

Dominant lethal test

MUTATION DATA

TYPE OF TEST :

Morphological transformation

TEST SYSTEM :

Rodent - hamster Embryo

REFERENCE :

EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1972- Volume(issue)/page/year: 25,75,1982 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 207 mg/m3 (100 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 103 mg/m3 (50 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,161,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,161,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,246,1987 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:air-CL 100 ppm (210 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,160,1971 OSHA PEL (Gen Indu):8H TWA 100 ppm;CL 200;Pk 300/5M/3H CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 100 ppm (210 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 100 ppm (210 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 100 ppm (210 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 50 ppm (105 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 50 ppm (105 mg/m3);STEL 100 ppm (205 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 50 ppm (105 mg/m3) JAN 1993 OEL-BELGIUM:TWA 50 ppm (103 mg/m3);STEL 100 ppm (207 mg/m3) JAN 1993 OEL-DENMARK:TWA 50 ppm (105 mg/m3) JAN 1993 OEL-FINLAND:TWA 50 ppm (105 mg/m3);STEL 75 ppm (160 mg/m3) JAN 1993 OEL-FRANCE:TWA 50 ppm (105 mg/m3);STEL 100 ppm (210 mg/m3) JAN 1993 OEL-GERMANY:TWA 50 ppm (105 mg/m3);Carcinogen JAN 1993 OEL-HUNGARY:TWA 20 mg/m3;STEL 40 mg/m3 JAN 1993 OEL-JAPAN:TWA 50 ppm (100 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 50 ppm (105 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 100 ppm (210 mg/m3) JAN 1993 OEL-POLAND:TWA 20 mg/m3 JAN 1993 OEL-RUSSIA:TWA 50 ppm;STEL 5 mg/m3 JAN 1993 OEL-SWEDEN:TWA 50 ppm (100 mg/m3);STEL 100 ppm (200 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 50 ppm (105 mg/m3);STEL 100 ppm (210 mg/m3) JAN 1993 OEL-THAILAND:TWA 100 mg/m3;STEL 200 mg/m3 JAN 1993 OEL-TURKEY:TWA 100 ppm (210 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 50 ppm (105 mg/m3);STEL 100 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL CHLORIDE-air:CA lowest feasible concentration REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0421 No. of Facilities: 1937 (estimated) No. of Industries: 32 No. of Occupations: 29 No. of Employees: 8804 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0421 No. of Facilities: 596 (estimated) No. of Industries: 18 No. of Occupations: 38 No. of Employees: 10003 (estimated) No. of Female Employees: 571 (estimated)

毒理学数据：

1.急性毒性^[16]

LC50：5300mg/m³（大鼠吸入，4h）

2.刺激性  暂无资料

3.致突变性^[17]  微生物致突变：鼠伤寒沙门菌2500ppm。姐妹染色单体交换：人淋巴细胞3%。哺乳动物体细胞突变：人淋巴细胞5%。程序外DNA合成：大鼠肝1%。显性致死试验：大鼠吸入3000ppm，每天6h，连续5d。

4.致畸性^[18]  大鼠孕后7~19d吸入最低中毒剂量（TCLo）1500ppm/6h，致肌肉骨骼系统发育畸形。小鼠孕后6~17d吸入最低中毒剂量（TCLo）500ppm/6h，致心血管系统发育畸形。

5.致癌性^[19]  IARC致癌性评论：G3，对人及动物致癌性证据不足。

6.其他^[20]  生殖毒：影响睾丸和精原细胞。胚胎发育毒物。LCLo：2000ppm（人吸入，2h）

生态数据：

1.生态毒性^[21]

LC50：270ppm（96h）（月银汉鱼，静态）；550ppm（96h）（蓝鳃太阳鱼，静态）

IC50：500~1450mg/L（72h）（藻类）

2.生物降解性  暂无资料

3.非生物降解性^[22]  空气中，当羟基自由基浓度为5.00×10⁵个/cm³时，降解半衰期为310d（理论）。

中国海关编码：2903110000

概述：

2903110000 一氯甲烷及氯乙烷。监管条件:无。增值税率:17.0%。退税率:9.0%。最低关税:5.5%。普通关税:30.0%

申报要素：

品名, 成分含量, 用途, 原产地证据文件及编号(例 附原产地证书, 原产于英国、美国、荷兰、德国、韩国的

摘要/Summary：

2903110000 chloroethane。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0%

分子结构数据

1、摩尔折射率：11.53

2、摩尔体积（cm³/mol）：56.4

3、等张比容（90.2K）：110.3

4、表面张力（dyne/cm）：14.6

5、极化率（10-24cm3）：4.57

计算化学数据

1、疏水参数计算参考值（XlogP）：0.8

2、氢键供体数量：0

3、氢键受体数量：0

4、可旋转化学键数量：0

5、互变异构体数量：无

6、拓扑分子极性表面积（TPSA）：0

7、重原子数量：2

8、表面电荷：0

9、复杂度：2

10、同位素原子数量：0

11、确定原子立构中心数量：0

12、不确定原子立构中心数量：0

13、确定化学键立构中心数量：0

14、不确定化学键立构中心数量：0

15、共价键单元数量：1

• 
  氯甲烷核磁图(¹HNMR)