二氯一氟甲烷; 一氟二氯甲烷

外观与性状：

无色气体或压缩液化气体,带有特有的气味

密度：

1,354 g/cm3

熔点：

-135°C

沸点：

8.9°C

闪点：

130-132°C/3mm

折射率：

1.3724 (9C)

存储条件/存储方法：

库房通风低温干燥,与易燃物分开存放

稳定性相关：

1.受热时分解成含氯化氢、氟化氢和光气的腐蚀性和有毒烟雾。各种合成橡胶在一氟二氯甲烷中发生溶胀。

2.稳定性^[17]  稳定

3.禁配物^[18]  强氧化剂、碱金属、碱土金属、易燃或可燃物

4.聚合危害^[19]  不聚合

5.分解产物^[20]  氟化氢、氯化氢

其它信息：

1.性状：无色、有似四氯化碳气味的气体。^[1]

2.熔点（℃）：-135^[2]

3.沸点（℃）：8.9^[3]

4.相对密度（水=1）：1.405（9℃）^[4]

5.相对蒸气密度（空气=1）：3.8^[5]

6.饱和蒸气压（kPa）：159（21℃）^[6]

7.临界温度（℃）：178.5^[7]

8.临界压力（MPa）：5.18^[8]

9.辛醇/水分配系数：1.55^[9]

10.闪点（℃）：-36^[10]

11.引燃温度（℃）：522^[11]

12.溶解性：不溶于水，溶于乙醇、乙醚、四氯化碳。^[12]

13.蒸气压（kPa,0ºC）：70.86

14.蒸气压（kPa,20ºC）：153.18

15.蒸气压（kPa,40ºC）：295.87

16.Lennard-Jones参数（A）：7.318

17.Lennard-Jones参数（K）：227.7

18.溶度参数(J·cm^-3)^0.5：13.608

19.van der Waals面积（cm²·mol^-1）：8.240×10⁹

20.van der Waals体积（cm³·mol^-1）：55.140

21.液相标准热熔(J·mol^-1·K^-1)：107.2

22.气相标准声称热(焓)( kJ·mol^-1) ：-284.9

23.气相标准熵(J·mol^-1·K^-1) ：293.1

24.气相标准生成自由能( kJ·mol^-1)：-254.4

25.气相标准热熔(J·mol^-1·K^-1)：60.9

包装等级：

III

风险类别：

2.2

危险类别码：

R59

安全说明：

59

RTECS号：

PA8400000

危险标志：

N:Dangerousfortheenvironment;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

PA8400000

CHEMICAL NAME :

Methane, dichlorofluoro-

CAS REGISTRY NUMBER :

75-43-4

BEILSTEIN REFERENCE NO. :

1731041

LAST UPDATED :

199712

DATA ITEMS CITED :

40

MOLECULAR FORMULA :

C-H-Cl2-F

MOLECULAR WEIGHT :

102.92

WISWESSER LINE NOTATION :

GYGF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

49900 ppm/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,187,1986

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>800 gm/m3/2H

TOXIC EFFECTS :

Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 20(11),38,1976

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

10 pph/1H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FLCRAP Fluorine Chemistry Reviews. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1967- Volume(issue)/page/year: 1,197,1967 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1 pph/6H/2W-I

TOXIC EFFECTS :

Liver - other changes

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41(1),199,1977

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1000 ppm/6H/90D-I

TOXIC EFFECTS :

Skin and Appendages - hair Related to Chronic Data - death

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41(1),200,1977

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

1 pph/3.5H/4W-I

TOXIC EFFECTS :

Liver - hepatitis (hepatocellular necrosis), zonal Liver - fatty liver degeneration

REFERENCE :

ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 21,149,1971

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

5000 ppm/6H/13W-I

TOXIC EFFECTS :

Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0520832

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

1 pph/3.5H/4W-I

TOXIC EFFECTS :

Liver - hepatitis (hepatocellular necrosis), zonal Liver - fatty liver degeneration

REFERENCE :

ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 21,149,1971

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

1 pph/3.5H/4W-I

TOXIC EFFECTS :

Liver - hepatitis (hepatocellular necrosis), zonal Liver - fatty liver degeneration Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 21,149,1971 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

1 pph/6H

SEX/DURATION :

female 6-15 day(s) after conception

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 45,293,1978 *** REVIEWS *** ACGIH TLV-TWA 42 mg/m3 (10 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 18,365,1974 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1000 ppm (4200 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,81,1971 OSHA PEL (Gen Indu):8H TWA 1000 ppm (4200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1000 ppm (4200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1000 ppm (4200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1000 ppm (4200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (40 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-BELGIUM:TWA 10 ppm (42 mg/m3) JAN 1993 OEL-DENMARK:TWA 10 ppm (40 mg/m3) JAN 1993 OEL-FINLAND:TWA 10 ppm (40 mg/m3);STEL 20 ppm (80 mg/m3) JAN 1993 OEL-FRANCE:TWA 10 ppm (40 mg/m3) JAN 1993 OEL-GERMANY:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-HUNGARY:STEL 40 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 10 ppm (42 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 1000 ppm (4200 mg/m3) JAN 1993 OEL-POLAND:TWA 2000 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (40 mg/m3);STEL 20 ppm (80 mg/m3) JAN 1993 OEL-TURKEY:TWA 1000 ppm (4200 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (40 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DICHLOROMONOFLUOROMETHANE-air:10H TWA 10 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 24235 No. of Facilities: 4131 (estimated) No. of Industries: 44 No. of Occupations: 56 No. of Employees: 43521 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 24235 No. of Facilities: 935 (estimated) No. of Industries: 8 No. of Occupations: 13 No. of Employees: 12182 (estimated) No. of Female Employees: 1640 (estimated)

毒理学数据：

1.急性毒性^[13]

LC50：499000ppm（大鼠吸入，4h）；＞800000mg/m³（小鼠吸入，2h）

2.刺激性  暂无资料

3.亚急性与慢性毒性^[14]  大鼠在0.5mg/L或1.5mg/L浓度下全天吸入，40d后可见鼻黏膜上皮破坏及刺激，同时伴有上皮化生。

生态数据：

1.生态毒性  暂无资料

2.生物降解性  暂无资料

3.非生物降解性^[15]  空气中，当羟基自由基浓度为5.00×10⁵个/cm³时，降解半衰期为1.5a（理论）。

4.其他有害作用^[16]  该物质臭氧消耗潜能（ODP）为0.04，可对大气臭氧层造成破坏。

分子结构数据

1、摩尔折射率：16.5

2、摩尔体积（cm³/mol）：73.6

3、等张比容（90.2K）：155.7

4、表面张力（dyne/cm）：19.9

5、介电常数：无可用

6、偶极距（10^-24cm³）：无可用

7、极化率：6.54

计算化学数据

1.疏水参数计算参考值（XlogP）:2

2.氢键供体数量:0

3.氢键受体数量:1

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积0

7.重原子数量:4

8.表面电荷:0

9.复杂度:13.5

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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  一氟二氯甲烷核磁图(¹HNMR)