首页产品供求市场行情现货直销公司信息
产品
产品 公司 求购 资讯 法规
English
  1. 您当前位置：
  2. 首页
  3. 产品数据
  4. 氯苯胍

氯苯胍

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 毒理性
  • 结构与计算化学
  • 上游产品

氯苯胍 基本信息

中文名称：
氯苯胍 
中文别名：
氯苯胍;
氯胍;
N-(4-氯苯基)-N'-(异丙基)-双胍 
英文名称：
Imidodicarbonimidicdiamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-
英文别名：
proguanil;
chlorguanide;
PROGUANIL;
paludrine;
ChlorguanideCl;
chloroguanide;
N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE;
Chlorguanide-D6Cl;
bigumal 
CAS No.：
500-92-5
分 子 式：

C11H16ClN5

分 子 量：
253.73
精确分子量：
253.10900
PSA：
83.79000
EINECS：
207-915-6
InChI：
The Key: SSOLNOMRVKKSON-UHFFFAOYSA-N
危险品标志：

 

风险术语：

 

安全术语：

 

分子结构式：
SDS：
查看

氯苯胍 制备方法及用途

制备方法

由硫氯酸钠与水合肼加成、重排,最后经甲醛在乙醇中缩合而制得。

合成制备方法

由硫氯酸钠与水合肼加成、重排，最后经甲醛在乙醇中缩合而制得。

用途简介

具有广谱、高效、低毒、安全范围大、适口性好和促进身长发育的特点。可用于防治鸡、兔球虫病的优良药物,对人畜共患弓形体病有预防和治疗作用。

用途

具有广谱、高效、低毒、安全范围大、适口性好和促进身长发育的特点。可用于防治鸡、兔球虫病的优良药物，对人畜共患弓形体病有预防和治疗作用。

氯苯胍 物化性质

密度：
1.29g/cm3
沸点：
402.7ºC at 760mmHg
闪点：
197.4ºC

氯苯胍 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DU1225000
CHEMICAL NAME :
Biguanide, 1-(p-chlorophenyl)-5-isopropyl-
CAS REGISTRY NUMBER :
500-92-5
BEILSTEIN REFERENCE NO. :
2811599
LAST UPDATED :
199612
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C11-H16-Cl-N5
MOLECULAR WEIGHT :
253.77
WISWESSER LINE NOTATION :
GR DMYUM&MYUM&MY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14XBAV "International Congress of Chemotherapy, Proceedings of the 3rd Congress, 1963," Kuemmerle, H.P., and Prezios, P., Stuttgart, Fed. Rep. Ger., Georg Thieme Verlag, 1964 Volume(issue)/page/year: -,367,1964
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 4,14,1949
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg/5D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 5,438,1950 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
700 mg/kg
SEX/DURATION :
female 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO. Volume(issue)/page/year: 10,361,1964
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
70 mg/kg
SEX/DURATION :
female 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 13,228,1968
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
504 mg/kg
SEX/DURATION :
female 42 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO. Volume(issue)/page/year: 10,361,1964
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
252 mg/kg
SEX/DURATION :
female 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO. Volume(issue)/page/year: 10,361,1964

氯苯胍 分子结构与计算化学数据

分子结构数据

1、  摩尔折射率：67.91

2、  摩尔体积（cm3/mol）：196.4

3、  等张比容（90.2K）：511.6

4、  表面张力（dyne/cm）：45.9

5、  极化率（10-24cm3）：26.92

推荐供应商更多供应商>>

上海源叶生物科技有限公司
产品介绍：
产品名称：500-92-5 Cas号：500-92-5 纯度：99% 包装信息：25mg,10mg 价格：450.0元 - 1,000.0元
联系方式：
联系人：Yuki 电话：021-61845781 手机：13585604150

湖北恩星生物科技有限公司
产品介绍：
产品名称：氯苯胍 Cas号：500-92-5 纯度： 包装信息：100kg,200kg,300kg,400kg,500kg 价格：64.0元 - 100.0元
联系方式：
联系人：邵经理 电话：16621771607 手机：16621771607

武汉琼格生物科技有限公司
产品介绍：
产品名称：N1-(4-氯苯基)-N5-异丙基双胍 Cas号：500-92-5 纯度：≥97% 包装信息：0.25g,0.25g,0.25g,0.25g,0.25g 价格：1,084.0元 - 1,084.0元
联系方式：
联系人：时燕 电话：027-84235681 手机：13657207535

郑州力本生物技术有限公司
产品介绍：
产品名称：氯胍 Cas号：500-92-5 纯度：99 包装信息：25/桶kg 价格：洽谈
联系方式：
联系人：刘林 电话：0371-86536307 手机：13949119001

@2009-2024 洛克化工网 浙ICP备16009103号 版权声明