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曲司氯铵
- 基本信息
- 制备方法及用途
- 物化性质
- 毒理性
- 上游产品
曲司氯铵 基本信息
- 中文名称：
- 曲司氯铵
- 中文别名：
- 曲司氯铵;
曲司氯胺
- 英文名称：
- Trospium chloride
- 英文别名：
- Trospium Chloride;
Trospium chloride
- CAS No.：
- 10405-02-4
- 分 子 式：
- C25H30NO3
- 分 子 量：
- 427.97
- 精确分子量：
- 427.19100
- PSA：
- 46.53000
- EINECS：
- 233-875-4
- InChI：
- InChI=1/C25H30NO3/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26/h1-6,9-12,21-23,28H,7-8,13-18H2/q+1/t21-,22+,23+
- 分子结构式：
-
- SDS：
- 查看
曲司氯铵 制备方法及用途
制备方法
抗胆碱药，用于治疗尿失禁、尿急和尿频等膀胱过度活动症。
用途简介
曲司氯铵 物化性质
- 外观与性状：
- 白色至灰白色粉末
- 熔点：
- 266-268ºC
曲司氯铵 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- WH1424000
- CHEMICAL NAME :
- Spiro(1-alpha-H,5-alpha-H-nortropane-8,1'-pyrrolidini
um), 3-alpha-hydroxy-, chloride, benzilate
- CAS REGISTRY NUMBER :
- 10405-02-4
- LAST UPDATED :
- 199312
- DATA ITEMS CITED :
- 18
- MOLECULAR FORMULA :
- C25-H30-N-O3.Cl
- MOLECULAR WEIGHT :
- 428.01
- WISWESSER LINE NOTATION :
- T56 A AKTJ GQ A-& AT5KTJ &G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 2571 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Autonomic Nervous System - parasympatholytic
Cardiac - pulse rate increase, without fall in BP
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 43,461,1993
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1510 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 97700 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 707 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15500 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraduodenal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 25,1037,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 812 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 203 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 11200 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - respiratory depression
Gastrointestinal - nausea or vomiting
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3200 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - altered sleep time (including change in righting reflex)
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15240 mg/kg/30D-C
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
Gastrointestinal - other changes
Related to Chronic Data - death
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3822 mg/kg/13W-C
- TOXIC EFFECTS :
- Liver - other changes
Endocrine - other changes
Related to Chronic Data - death
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 246 mg/kg/30D-C
- TOXIC EFFECTS :
- Endocrine - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 315 mg/kg/30D-C
- TOXIC EFFECTS :
- Cardiac - other changes
Lungs, Thorax, or Respiration - other changes
Related to Chronic Data - death
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1560 mg/kg/13W-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,199,1974
湖北诺纳科技有限公司
- 产品介绍：
-
产品名称：曲司氯铵
Cas号：10405-02-4
纯度：99%
包装信息：1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶
价格：1.0元 - 25.0元
- 联系方式：
-
联系人：张经理
电话：027-59209883
手机：17386169806
湖北帝柏化工有限公司
- 产品介绍：
-
产品名称：曲司氯胺
Cas号：10405-02-4
纯度：99%
包装信息：1kg,10kg,25kg,50kg,100kg
价格：14.0元 - 18.0元
- 联系方式：
-
联系人：雷经理
电话：15872383390
手机：15872383390
湖北云镁科技有限公司
- 产品介绍：
-
产品名称：曲司氯铵
Cas号：10405-02-4
纯度：99%
包装信息：320kg,1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶
价格：1.0元 - 320.0元
- 联系方式：
-
联系人：方经理
电话：027-59206672
手机：18327059871
山东默派生物科技有限公司
- 产品介绍：
-
产品名称：曲司氯铵
Cas号：10405-02-4
纯度：99%
包装信息：多种包装规格kg
价格：洽谈
- 联系方式：
-
联系人：谭经理
电话：13053322091
手机：13053322091
上海吉至生化科技有限公司
- 产品介绍：
-
产品名称：曲司氯胺
Cas号：10405-02-4
纯度：99%
包装信息：100mgea
价格：151.0元
- 联系方式：
-
联系人：Shirley张
电话：021-57520831
手机：18116052675
沧州恩科医药科技有限公司
- 产品介绍：
-
产品名称：曲司氯铵
Cas号：10405-02-4
纯度：99%
包装信息：100kg,200kg,300kg,400kg,500kg
价格：64.0元 - 100.0元
- 联系方式：
-
联系人：赵经理
电话：0317-5106598
手机：13323075105
上海瀚思化工有限公司
- 产品介绍：
-
产品名称：曲司氯铵
Cas号：10405-02-4
纯度：98%
包装信息：100mg
价格：798.4元
- 联系方式：
-
联系人：张
电话：021-64806089
手机：18049821080
山东英朗化工有限公司
- 产品介绍：
-
产品名称：曲司氯铵
Cas号：10405-02-4
纯度：99%
包装信息：100kg
价格：50.0元
- 联系方式：
-
联系人：李
电话：15725413579
手机：
杭州鼎燕化工有限公司
- 产品介绍：
-
产品名称：曲司氯胺
Cas号：10405-02-4
纯度：99%
包装信息：1kg
价格：100.0元
- 联系方式：
-
联系人：Yuri
电话：0571-87157530
手机：18267553885
湖北恩星生物科技有限公司
- 产品介绍：
-
产品名称：曲司氯铵
Cas号：10405-02-4
纯度：
包装信息：100kg,200kg,300kg,400kg,500kg
价格：64.0元 - 100.0元
- 联系方式：
-
联系人：邵经理
电话：16621771607
手机：16621771607
