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羟普鲁卡因
- 基本信息
- 物化性质
- 安全信息
- 毒理性
- 海关数据
- 结构与计算化学
- 上游产品
- 下游产品
羟普鲁卡因 基本信息
- 中文名称：
- 羟普鲁卡因
- 中文别名：
- 羟普鲁卡因;
2-(二乙基氨基)乙基4-氨基-2-羟基苯甲酸酯
- 英文名称：
- Benzoic acid,4-amino-2-hydroxy-, 2-(diethylamino)ethyl ester
- 英文别名：
- 2-(diethylamino)ethyl 4-amino-2-hydroxybenzoate;
4-Amino-2-hydroxy-benzoesaeure-(2-diaethylamino-aethylester);
Metahydroxyprocaine;
Oxyprocain;
Hydroxyprocaine;
Oxycaine;
Hydroxynovocain;
2-Diethylaminoethyl p-aminosalicylate;
4-Amino-salicylsaeure-(2-diethylamino-ethylester);
Oxyprocaine;
m-Hydroxyprocaine;
Oxiprocainum;
4-Amino-2-hydroxy-benzoesaeure-(2-diethylamino-ethylester);
p-Amino-salicylsaeure-diaethylaminoaethyl-ester;
Hydroxy-procain;
4-amino-2-hydroxy-benzoic acid-(2-diethylamino-ethyl ester);
Diethylaminoethyl p-aminosalicylate
- CAS No.：
- 487-53-6
- 分 子 式：
-
C13H20N2O3
- 分 子 量：
- 252.31
- 精确分子量：
- 252.14700
- PSA：
- 75.79000
- EINECS：
- 207-660-0
- InChI：
- The Key: GHSCYMOJHVOGDJ-UHFFFAOYSA-N
- 危险品标志：
-
- 风险术语：
-
- 安全术语：
- 分子结构式：
-
- SDS：
- 查看
羟普鲁卡因 物化性质
- 密度：
- 1.158g/cm3
- 沸点：
- 408.7ºC at 760mmHg
- 闪点：
- 201ºC
- 折射率：
- 1.565
- 蒸汽压：
- 2.9E-07mmHg at 25°C
羟普鲁卡因 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VO1575000
- CHEMICAL NAME :
- Salicylic acid, 4-amino-, 2-(diethylamino)ethyl ester
- CAS REGISTRY NUMBER :
- 487-53-6
- BEILSTEIN REFERENCE NO. :
- 2650192
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C13-H20-N2-O3
- MOLECULAR WEIGHT :
- 252.35
- WISWESSER LINE NOTATION :
- ZR CQ DVO2N2&2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 190 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
31,97,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 36 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
31,97,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 125 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 2,112,1952
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
31,97,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 47 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
31,97,1953
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 72 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 10,284,1951
羟普鲁卡因 海关数据
中国海关编码：2922509090
- 概述：
- 2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%
- 申报要素：
- 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
- 监管条件：
- A.入境货物通关单B.出境货物通关单
- 检验检疫：
- R.进口食品卫生监督检验S.出口食品卫生监督检验
- 摘要/Summary：
- 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
羟普鲁卡因 分子结构与计算化学数据
计算化学数据
1.疏水参数计算参考值（XlogP）:无
2.氢键供体数量:2
3.氢键受体数量:5
4.可旋转化学键数量:7
5.互变异构体数量:12
6.拓扑分子极性表面积:75.8
7.重原子数量:18
8.表面电荷:0
9.复杂度:257
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1
