催产素

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 结构与计算化学
  • 上游产品
  • 下游产品

催产素 基本信息

中文名称:
催产素 
中文别名:
催产素;
N-苄氧羰基-S-苄基半胱氨酰酪氨酰异亮氨酰谷氨酰胺酰天冬酰胺酰(S-苄基)半胱氨酰脯氨酰;
缩宫素;
醋酸催产素 
英文名称:
Oxytocin
英文别名:
oxytocin;
Oxtocin;
α-Hypophamine Oxytocic hormone 
CAS No.:
50-56-6
分 子 式:

C43H66N12O12S2

分 子 量:
1007.19
精确分子量:
1006.44000
PSA:
450.13000
MDL:
MFCD00076731
EINECS:
200-048-4
BRN:
3586108
InChI:
InChI=1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56
危险品标志:

 

风险术语:

R36/37/38;

安全术语:

S26;S36;

分子结构式:
SDS:
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催产素 制备方法及用途

制备方法

方法一、提取法(我国目前采用方法,纯度较低,但成本低) 缩宫素液的提取 取后叶干粉100g,石英粉30g放人球磨机中,加入蒸馏水,同法提取四次。加入蒸馏水的量依次为1.4L两次,1.3L两次。每次提取45min,离心,收集液体,残渣再进行提取。合并四次提取液,即得缩宫素液。后叶干粉[水,球磨机]→缩宫素提取液层析分离 将事先处理好的人造沸石1500g,加入20L的0.25%乙酸溶液,搅拌后倒人交换柱中,待乙酸液下降至沸石表面以上2-3cm处时,即加入提取液,于适当流速下收集白色浑浊液(主要含缩宫素,因其pI7.7,而加压素 pI10.9,易成为正离子而被吸附)。当提取液液面下降到沸石表面时,立即加入蒸馏水,继续收集浑浊液,直到流尽为止。将浑浊液用冰醋酸调pH为3.5,于水浴迅速加热至95℃保持3min,迅速冷却并冷藏过夜。缩宫素提取液[HAc, 人造沸石柱]→浑浊液[HAc, 加热]→分离液吸附、洗脱 次日,将冷藏液过滤,滤液在搅拌下加入10%皂土浆 (每100ml加3ml),搅拌1h吸附,离心。上清液用磺基水杨酸试液检查,不发生沉淀为吸附完全。若不完全,再次吸附,合并两次皂土浆沉淀。皂土用1%乙酸分四次洗脱(分别为1.6L、1.4L、1.2L、0.8L),每次的洗脱液加热到80℃时加入三氯叔丁醇,再升温至95℃,速冷至25℃,过滤或离心,合并四次滤液,检测效价和加压素限度。冷藏液[过滤]→滤液[皂土浆]→吸附物[1% HAc]→洗脱液缩宫素注射液的制备 将测得的合格缩宫素液,稀释到5U/ml或10U/ml,经4号或5号垂熔漏斗过滤,灌封,100℃流通蒸气灭菌30min,即得成品。缩宫素液(测定合格)[过滤灌封,灭菌]→缩宫素注射液。注:人造沸石处理 新沸石经60-80目筛后,每500g加2L蒸馏水,氢氧化钠调至pH9,保持半小时,倾去上清液,再加水2L,调至pH9,再倾去上清液,加水,搅拌并加稀硫酸使pH下降到5.8-6搅拌半小时,倾去上清液,再每次用儿水,反复洗7-8次。加水1L和稀硫酸,搅拌半小时,倾去上清液,用水洗至pH7,滤干,干燥备用。人造沸石的再生 将人造沸石用蒸馏水洗2次,然后加1.5L的水(按沸石500g计算)和氯化钠150g搅拌2h,洗涤除去加压素,再用蒸馏水洗到无氯离子为止。加适量水,用氢氧化钠调节pH至9,搅拌半小时,倾去上清液,用蒸馏水洗涤,以硫酸调节pH至5.5-6,再用水洗至近中性,滤干,在105℃烘干备用。用前加适量水,并用冰醋酸调节,搅拌浸泡。10%皂土浆的制备 按皂土质量与水的体积比为1:10的比例混合,研磨约1h,并在研磨中用乙酸调节pH稳定在3.5,放置冰箱中备用。方法二、化学合成法先从苄氧碳酰亮氨酸对硝基苯酯合成7肽酰胺(3-9段),再合成苄氧羰酰-S-苄基半胱·酪氨酰叠氮(1-2段),第三步合成缩宫素。

合成制备方法

1.催产素和加压素都为九肽,加压素分子中有一碱性氨基酸残基,两者等电点不同。催产素等电点为7.7,加压素等电点为10.9,即加压素碱性较强。将含有这二种激素的提取液通入人造沸石柱时,加压素易形成带正电离子而绝大部分被吸附,催产素通过沸石柱而流出。流出的催产素溶液,用皂土处理,可得较纯的催产素。

垂体后叶干粉提取↓水分离↓沸石柱去杂蛋白↓乙酸

皂土吸附↓皂土解吸↓乙酸催产素

将垂体后叶干粉100g和石英粉约30g加入蒸馏水1.4L中,于球磨中球磨提取45min,离心,收集上层清液。残渣再分别加水1.4L、1.3L、1.3L按上法再提取3次。将4次离心上清液合并。将处理好的人造沸石1500g,加入0.25%醋酸溶液20L,搅拌后装入交换柱中,待交换柱中0.25%醋酸液下降到沸石表面以下2~3cm处时,立即加入提取液,适当调节流速,收集吸附柱开始流出的白色浑浊液。当提取液液面下降到沸石表面时,立即续加蒸馏水,待浊液流尽后停止收集。流经沸石的提取液用冰醋酸调节pH=3.5,再用水浴迅速加热至95℃保持3min,立即冷却,0~5℃冷室放置过夜。次日过滤,得澄清滤液。然后将滤液在搅拌下,加入事先处理好的10%皂土浆(一般每100ml加3ml),连续搅拌1h,上清液应检查吸附是否完全(以20%磺基水杨酸溶液检查,应不发生沉淀),如吸附不完全,应再加皂土浆吸附。2次皂土沉淀合并。再将皂土用1%醋酸溶液解吸。总用量为5L分4次解吸,用量分别为1.6L、1.4L、1.2L和0.8L,合并4次解吸液。测定解吸液中催产素和加压素的含量,按催产素效价计算,如加压素未超过限度,即得催产素溶液。

用途简介

缩宫素能从口腔黏膜吸收,并选择性地作用于子宫平滑肌,促使子宫收缩。适用于催生及阵痛迟缓。效果与静滴后叶催产素相同。对于骨盆狭窄、有子宫手术史(包括剖腹产)、阵痛过度亢进、产道受阻、胎盘早剥、严重妊娠中毒产妇禁用。子宫收缩药。用于引产、催产、产后及流产后因宫缩无力等引起的子宫出血。滴鼻可促使排乳。

用途

1.对平滑肌有刺激作用,能使子宫平滑肌收缩,故有催产作用。可用于引产、催产及流产后因宫缩无力等引起的子宫出血。滴鼻可促使排乳。也有轻微止血作用。

催产素 物化性质

外观与性状:
冻干的粉末
密度:
1.27 g/cm3
熔点:
192-194°C
沸点:
1533.3ºC at760mmHg
闪点:
881.1ºC
存储条件/存储方法:

棕色玻璃瓶闭光密封包装。贮存于低温干燥处。

其它信息:

1.       性状:为白色无定形粉末,微有异臭

催产素 安全信息

包装等级:
II
风险类别:
6.1(a)
WGK_Germany:
3
德国有关水污染物质的分类清单
危险类别码:
R36/37/38
安全说明:
26-36
RTECS号:
RS7534000
安全标志:
S26:万一接触眼睛,立即使用大量清水冲洗并送医诊治。
S36:穿戴合适的防护服装。
危险标志:
Xi: Irritant;

催产素 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RS7534000
CHEMICAL NAME :
Oxytocin
CAS REGISTRY NUMBER :
50-56-6
LAST UPDATED :
199612
DATA ITEMS CITED :
29
MOLECULAR FORMULA :
C43-H66-N12-O12-S2
MOLECULAR WEIGHT :
1007.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>20520 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,230,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>20520 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,230,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2275 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,230,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>514 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,230,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>514 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,230,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,151,1982 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
82 ng/kg
SEX/DURATION :
female 37 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)
REFERENCE :
ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB 560B, Kennebunkport, ME 04046) V.1- 1926- Volume(issue)/page/year: 54,400,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
5760 uL/kg
SEX/DURATION :
female 39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - respiratory system Reproductive - Specific Developmental Abnormalities - hepatobiliary system Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
REFERENCE :
PPATDQ Pediatric Pathology. (Hemisphere Publishing Corp., c/o Taylor & Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.1- 1983- Volume(issue)/page/year: 12,761,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
20 ug/kg
SEX/DURATION :
female 21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,181,1974
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
650 ng/kg
SEX/DURATION :
female 21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,651,1975
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
30000 iu/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Maternal Effects - other effects
REFERENCE :
ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 125,109,1991
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
277 ng/kg
SEX/DURATION :
female 21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,941,1971
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
10 units/kg
SEX/DURATION :
female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 23,27,1988
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
DOSE :
175 ug/kg
SEX/DURATION :
female 17-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 101,121,1984
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
DOSE :
175 ug/kg
SEX/DURATION :
female 17-21 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 101,121,1984
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
DOSE :
500 ug/kg
SEX/DURATION :
female 17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - physical
REFERENCE :
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 15,383,1993
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
500 ng/kg
SEX/DURATION :
female 18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,181,1974
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
80 ug/kg
SEX/DURATION :
female 19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 36,188P,1969
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
80 ug/kg
SEX/DURATION :
female 19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 36,188P,1969
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
80 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 133,1254,1970
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
900 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 28,267,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
300 mg/kg
SEX/DURATION :
female 6-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
CEFYAD Ceskoslovenska Fysiologie. (Academia, Vodickova 40, 112 29 Prague 1, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 38,278,1989
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
150 ng/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 73,433,1963
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
2400 ng/kg
SEX/DURATION :
female 63-64 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 253,148,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
24 ug/kg
SEX/DURATION :
lactating female 1 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - postpartum
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 23,537,1970
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
1613 mg/kg
SEX/DURATION :
female 18-19 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 160,242,1989
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
50 ug/kg
SEX/DURATION :
female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year: 146,577,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
54 ng/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 18,259,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3710 No. of Facilities: 113 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 2515 (estimated) No. of Female Employees: 1568 (estimated)

催产素 MSDS


Section 1. Chemical Product and Company Identification
    Oxytocin
    Common Name/
    Trade Name
    Manufacturer
    Oxytocin

Section 4. First Aid Measures
    Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at    
    least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.
    Skin Contact        Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.    
    Cold water may be used.
    Serious Skin Contact        Not available.    
    Inhalation        If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get    
    medical attention.
    Serious Inhalation        Not available.    
    Ingestion        If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by    
    mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical
    attention immediately.
    Serious Ingestion        Not available.    

Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature Not available.
    Flash Points        Not available.    
    Flammable Limits        Not available.    
    These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), sulfur oxides (SO2, SO3...).
    Products of Combustion
    Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
    Various Substances
    Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
    of Various Substances        Risks of explosion of the product in presence of static discharge: Not available.    
    Fire Fighting Media        SMALL FIRE: Use DRY chemical powder.    
    and Instructions        LARGE FIRE: Use water spray, fog or foam. Do not use water jet.    
    Special Remarks on        As with most organic solids, fire is possible at elevated temperatures.    
    Fire Hazards        Material in powder form, capable of creating a dust explosion.    
    Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust
    Hazards        explosion hazard.    

Section 6. Accidental Release Measures
    Small Spill        Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by    
    spreading water on the contaminated surface and dispose of according to local and regional authority
    requirements.
    Large Spill
    Poisonous solid.
    Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to
    reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition
    allow to evacuate through the sanitary system.
    Oxytocin

Section 7. Handling and Storage
    Precautions        Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not    
    ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and
    show the container or the label.
    Storage        Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 8°C (46.4°F).    
    Refrigerate.

Section 8. Exposure Controls/Personal Protection
    Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below    
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
    airborne contaminants below the exposure limit.
    Personal Protection        Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.    
    Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
    a Large Spill        to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist    
    BEFORE handling this product.
    Exposure Limits        Not available.    

Section 9. Physical and Chemical Properties
    Physical state and appearance Solid. (Powdered solid.)        Odor        Not available.    
    Taste        Not available.    
    Molecular Weight        1007.19 g/mole    
    Color        White. Off-white.    
    pH (1% soln/water)        Not available.    
    Not available.
    Boiling Point
    Melting Point        Not available.    
    Not available.
    Critical Temperature
    Specific Gravity        Not available.    
    Vapor Pressure        Not applicable.    
    Vapor Density        Not available.    
    Volatility        Not available.    
    Odor Threshold        Not available.    
    Water/Oil Dist. Coeff.        Not available.    
    Ionicity (in Water)        Not available.    
    Dispersion Properties        See solubility in water.    
    Solubility        Soluble in cold water.    
    Soluble in 1-Butanol and 2-Butanol

Section 10. Stability and Reactivity Data
    Stability        The product is stable.    
    Not available.
    Instability Temperature
    Conditions of Instability        Excess heat    
    Incompatibility with various        Not available.    
    substances
    Corrosivity        Not available.    
    Oxytocin
    Special Remarks on        Not available.    
    Reactivity
    Special Remarks on        Not available.    
    Corrosivity
    Polymerization        Will not occur.    

Section 11. Toxicological Information
    Routes of Entry        Inhalation. Ingestion.    
    Toxicity to Animals        Acute oral toxicity (LD50): >20.52 mg/kg [Rat].    
    Chronic Effects on Humans Not available.
    Other Toxic Effects on        Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.    
    Humans
    Special Remarks on
    Not available.
    Toxicity to Animals
    Special Remarks on        May cause adverse reproductive effects and birth defects (teratogenic)    
    Chronic Effects on Humans
    Special Remarks on other        Acute Potential Health Effects:    
    Toxic Effects on Humans        Skin: May cause skin irritation.    
    Eyes: May cause eye irritation.
    Inhalation: Dust may cause respiratory tract irritation.
    Ingestion: May be harmful if swallowed. May cause flushing, headache, somnolence, nausea and vomiting. May
    also cause hypotension followed by hypertension, bradycardia, tachycardia, arteriospasm, fluid and electrolyte
    imbalance, and possible seizures. It may also affect the kidneys. Blurred vision and conjunctival hemorrhage,
    anxiety, difficulty breathing are rare complications.
    Chronic Potential Health Effects:
    Ingestion: Prolonged or repeated ingesiton may cause allergic (anaphylactoid) reaction.
    Note: Uterine rupture or tears may result from high dose Oxytocin. The use of Oxytocin to induce labor may
    result in intrauterine transplacental hyponatremia which may cause neonatal seizures and respiratory depression.
    It may also cause neonatal hyperbilirubinemia and jaundice (effects on the liver).

Section 12. Ecological Information
    Not available.
    Ecotoxicity
    Not available.
    BOD5 and COD
    Products of Biodegradation        Possibly hazardous short term degradation products are not likely. However, long term degradation products may    
    arise.
    Toxicity of the Products        The products of degradation are less toxic than the product itself.    
    of Biodegradation
    Not available.
    Special Remarks on the
    Products of Biodegradation

Section 13. Disposal Considerations
    Waste Disposal        Waste must be disposed of in accordance with federal, state and local environmental    
    control regulations.
    Oxytocin

Section 14. Transport Information
    DOT Classification        Not a DOT controlled material (United States).    
    Identification        Not applicable.    
    Not applicable.
    Special Provisions for
    Transport
    DOT (Pictograms)

Section 15. Other Regulatory Information and Pictograms
    No products were found.
    Federal and State
    Regulations
    California        California prop. 65: This product contains the following ingredients for which the State of California has found    
    to cause cancer which would require a warning under the statute: No products were found.
    Proposition 65
    Warnings
    California prop. 65: This product contains the following ingredients for which the State of California has found
    to cause birth defects which would require a warning under the statute: No products were found.
    Other Regulations        OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).    
    EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No.
    200-048-4).
    Canada: Listed on Canadian Domestic Substance List (DSL).
    China: Not listed on National Inventory.
    Japan: Listed on National Inventory (ENCS).
    Korea: Not listed on National Inventory (KECI).
    Philippines: Not listed on National Inventory (PICCS).
    Australia: Listed on AICS.
    WHMIS (Canada) CLASS D-2A: Material causing other toxic effects (VERY TOXIC).
    Other Classifications
    DSCL (EEC)        R22- Harmful if swallowed.        S46- If swallowed, seek medical advice    
    immediately and show this container or label.
    Health Hazard
    HMIS (U.S.A.)        1 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    1 0 Reactivity
    Health
    Reactivity
    0
    Specific hazard
    Personal Protection
    E
    WHMIS (Canada)
    (Pictograms)
    DSCL (Europe)
    (Pictograms)
    TDG (Canada)
    (Pictograms)
    Oxytocin
    ADR (Europe)
    (Pictograms)
    Protective Equipment
    Gloves.
    Lab coat.
    Dust respirator. Be sure to use an
    approved/certified respirator or
    equivalent.


SECTION 16 - ADDITIONAL INFORMATION
N/A

催产素 分子结构与计算化学数据

计算化学数据

1、   疏水参数计算参考值(XlogP):-2.6

2、   氢键供体数量:12

3、   氢键受体数量:13

4、   可旋转化学键数量:17

5、   互变异构体数量:1001

6、   拓扑分子极性表面积(TPSA):400

7、   重原子数量:69

8、   表面电荷:0

9、   复杂度:1870

10、同位素原子数量:0

11、确定原子立构中心数量:9

12、不确定原子立构中心数量:0

13、确定化学键立构中心数量:0

14、不确定化学键立构中心数量:0

15、共价键单元数量:1

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