| 质量等级 | 包装(采购量区间) | 价格 | 库存 |
|---|---|---|---|
| 99% | 1kg铝箔袋/氟化瓶 | 1.00元 | 100 |
| 99% | 10kg铝听/纸箱 | 10.00元 | 100 |
| 99% | 25kg纸板桶/编织袋/塑料桶 | 25.00元 | 100 |
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| KW-2478 | |
|---|---|
| 参数 | 数值 |
| 生物活性 | KW-2478是一种非Ansamycin的HSP90抑制剂，IC50为3.8 nM。Phase 1。 |
| 体外研究 | KW-2478 inhibits the binding of bRD to Hsp90α with IC50 of 3.8 nM. KW-2478 degradates the Hsp90 client proteins, including FGFR3 IGF-1Rβc-Raf-1. KW-2478 reduces the level of phosphorylated Erk1/2. KW-2478 induces apoptosis by cleavage of PARP, a substrate of caspase-3 In U266 cells,. KW-2478 has Time dependency of antiproliferative activity, consecutive drug exposure fat least 12 hours is necessary to to exert potent antitumactivity. KW-2478 downregulates the translocation products of IgH locus. KW-2478 inhibits the transcription of c-Maf cyclin D1 genes by mainly suppressing the function of Cdk9. KW-2478 has potent broad growth inhibitory activities against various cell lines, KW-2478 inhibites cancer cell growth in all cell lines, with EC50 of 101-252 nM, 81.4-91.4 nM 120-622 nM fB-cell lymphoma, mantle cell lymphoma multiple myeloma, respectively. KW-2478 also shows potent growth inhibitory activity in primary CLL NHL cells with EC50 of 40-170 nM 200-400 nM, respectively. . |
| 体内研究 | KW-2478 suppresses tumgrowth induces the degradation of client proteins in tumors in NCI-H929 s.c. inoculated model at doses of 100 mg/kg more. KW-2478 reduces both serum M protein MM tumburden in the bone marrow in OPM-2/GFP i.v. inoculated mouse model at doses of 100 mg/kg. |
| 别名 | 2-乙基-3,5-二羟基-N,N-双(2-甲氧基乙基)-6-[3-甲氧基-4-[2-(4-吗啉基)乙氧基]苯甲酰基]苯乙酰胺 |
| 英文别名 | KW-2478;2-Ethyl-3,5-dihydroxy-N,N-bis(2-methoxyethyl)-6-[3-methoxy-4-[2-(4-morpholinyl)ethoxy]benzoyl]benzeneacetamide;2-(2-ethyl-3,5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N,N-bis(2-methoxyethyl)acetamide;2-Ethyl-3,5-dihydroxy-N,N-bis(2-methoxyethyl)-6-[3-methoxy-4-[2-(4-morpholinyl)ethoxy]benzoyl]benzeneacetamideKW2478;2-(2-Ethyl-3,5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N,N-bis(2-methoxye |
| KW-2478 | |
|---|---|
| 参数 | 数值 |
| 密度 | 1.209 |
硫酸铵(7783-20-2 ) | 乙烯基乙炔(689-97-4 ) | 氟虫腈(120068-37-3 ) | L-苯丙氨酸,4 [ 2-AMINO-6 -(3 - [ 2,2,2 -三氟-1 -氟[ 1,1'-联苯-4-乙氧基])] - 4-PYRIMIDINYL ]—(945976-43-2 ) | N,N-二羟丙基对甲苯胺 | 2-丙烯酸-2-羟基丙基酯 (999-61-1 ) | 硝酸异丙酯(1712-64-7 ) | 2-硝基环己酮(4883-67-4 ) | 三苯基膦(603-35-0 ) | VBL荧光增白剂(12224-16-7 ) |
