氟里昂-22

外观与性状：

无色气体

密度：

1,18 g/cm3

熔点：

-146°C

沸点：

-40.8°C

水溶解性：

Slightly soluble

折射率：

1.264 (22ºC)

存储条件/存储方法：

库房通风低温干燥,轻装轻卸,与易燃物分开存放

稳定性相关：

1.稳定性^[22]  稳定

2.禁配物^[23]  强氧化剂、易燃或可燃物

3.聚合危害^[24]  不聚合

4.分解产物^[25]  氟化氢

其它信息：

1.性状：无色气体，有轻微的甜气味。^[1]

2.熔点（℃）：-157^[2]

3.沸点（℃）：-40.8^[3]

4.相对密度（水=1）：1.21^[4]

5.相对蒸气密度（空气=1）：3.0^[5]

6.饱和蒸气压（kPa）：908（20℃）^[6]

7.燃烧热（kJ/mol）：-65.7^[7]

8.临界温度（℃）：96^[8]

9.临界压力（MPa）：4.91^[9]

10.辛醇/水分配系数：1.08^[10]

11.闪点（℃）：-78^[11]

12.引燃温度（℃）：632^[12]

13.溶解性：溶于水，溶于乙醚、氯仿、丙酮。^[13]

14.临界密度（g·cm^-3）：0.520

15.临界体积（cm³·mol^-1）：166

16.临界压缩因子：0.2670

17.偏心因子：0.219

18.Lennard-Jones参数（A）：4.6051

19.Lennard-Jones参数（K）：290.18

20.van der Waals面积（cm²·mol^-1）：4.690×10⁹

21.van der Waals体积（cm³·mol^-1）：31.020

22.液相标准热熔(J·mol^-1·K^-1)：111.7

23.气相标准声称热(焓)( kJ·mol^-1) ：-482.8

24.气相标准熵(J·mol^-1·K^-1) ：280.9

25.气相标准生成自由能( kJ·mol^-1)：-451.7

26.气相标准热熔(J·mol^-1·K^-1)：55.85

风险类别：

2.2

海关代码：

2903710000

危险类别码：

R40;R59

安全说明：

S23-S59

危险标志：

F

CHEMICAL IDENTIFICATION

RTECS NUMBER :

PA6390000

CHEMICAL NAME :

Methane, chlorodifluoro-

CAS REGISTRY NUMBER :

75-45-6

BEILSTEIN REFERENCE NO. :

1731036

LAST UPDATED :

199712

DATA ITEMS CITED :

44

MOLECULAR FORMULA :

C-H-Cl-F2

MOLECULAR WEIGHT :

86.47

WISWESSER LINE NOTATION :

GYFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD - Lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>43200 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

35 pph/15M

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1380 mg/m3/2H

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

70 pph

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

30 pph/2H

TOXIC EFFECTS :

Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2457 mg/kg/26W-I

TOXIC EFFECTS :

Brain and Coverings - other degenerative changes Blood - changes in other cell count (unspecified) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

50 gm/m3/6H/43W-I

TOXIC EFFECTS :

Brain and Coverings - other degenerative changes Spinal Cord - other degenerative changes Behavioral - alteration of classical conditioning

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

50000 ppm/5H

SEX/DURATION :

male 56 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

5 ppm

SEX/DURATION :

female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - eye/ear

MUTATION DATA

TYPE OF TEST :

Mutation in microorganisms

TEST SYSTEM :

Bacteria - Salmonella typhimurium

REFERENCE :

TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 2,1,1978 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 3540 mg/m3 (1000 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,237,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,237,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,149,1987 TOXICOLOGY REVIEW FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 18,365,1974 TOXICOLOGY REVIEW NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of New York, POB 5405, Lake Success, NY 11042) V.1- 1901- Volume(issue)/page/year: 74,1939,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1000 ppm (3500 mg/m3);STEL 1250 ppm JAN 1993 OEL-AUSTRIA:TWA 500 ppm (1800 mg/m3) JAN 1993 OEL-BELGIUM:TWA 1000 ppm (3540 mg/m3);STEL 1250 ppm JAN 1993 OEL-DENMARK:TWA 1000 ppm (3500 mg/m3) JAN 1993 OEL-FINLAND:TWA 1000 ppm (3500 mg/m3);STEL 1250 ppm JAN 1993 OEL-FRANCE:TWA 1000 ppm (3500 mg/m3) JAN 1993 OEL-GERMANY:TWA 500 ppm (1800 mg/m3) JAN 1993 OEL-HUNGARY:TWA 100 mg/m3;STEL 200 mg/m3 JAN 1993 OEL-JAPAN:TWA 1000 ppm (3500 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 1000 ppm (3500 mg/m3) JAN 1993 OEL-RUSSIA:TWA 1000 ppm;STEL 3000 mg/m3 JAN 1993 OEL-SWEDEN:TWA 500 ppm (1800 mg/m3);STEL 750 ppm (2500 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 500 ppm (1800 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 1000 ppm (3500 mg/m3);STEL 1250 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CHLORODIFLUOROMETHANE-air:TWA 1000 ppm;STEL 1250 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80048 No. of Facilities: 7420 (estimated) No. of Industries: 76 No. of Occupations: 44 No. of Employees: 56234 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80048 No. of Facilities: 12513 (estimated) No. of Industries: 78 No. of Occupations: 57 No. of Employees: 157080 (estimated) No. of Female Employees: 12185 (estimated)

毒理学数据：

1.急性毒性^[14]

LC50：35%（大鼠吸入，15min）

2.刺激性  暂无资料

3.亚急性与慢性毒性^[15]  兔、大鼠、小鼠吸入0.2%浓度，每天6h，共10个月，均无毒性反应；1.4%浓度，体重减轻，血清蛋白降低，球蛋白升高。剖检肺见肺泡间质增厚、肺水肿，心、肝、肾及神经系统退行性变。

4.致突变性^[16]  微生物致突变：鼠伤寒沙门菌33%（连续，24h）。微粒体诱变：鼠伤寒沙门菌33%（连续，24h）

5.致畸性^[17]  大鼠孕后6~15d吸入最低中毒剂量（TCLo）5ppm，致眼耳发育畸形。微生物致突变：鼠伤寒沙门菌33%（24h）

6.致癌性^[18]  IARC致癌性评论：G3，对人及动物致癌性证据不足。

7.其他^[19]  雄性大鼠吸入最低中毒浓度（TCLo）：50000ppm（每天5h，56d），对前列腺、精囊、Cowper氏腺、附属腺体、尿道产生影响。

生态数据：

1.生态毒性  暂无资料

2.生物降解性  暂无资料

3.非生物降解性^[20]  空气中，当羟基自由基浓度为5.00×10⁵个/cm³时，降解半衰期为9.4a（理论）。

4.其他有害作用^[21]  该物质的臭氧消耗潜能（ODP）为0.055，可对大气臭氧层造成破坏。

分子结构数据

1、摩尔折射率：11.81

2、摩尔体积（cm³/mol）：67.6

3、等张比容（90.2K）：126.7

4、表面张力（dyne/cm）：12.2

5、极化率（10-24cm3）：4.68

计算化学数据

1.疏水参数计算参考值（XlogP）:1.8

2.氢键供体数量:0

3.氢键受体数量:2

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积0

7.重原子数量:4

8.表面电荷:0

9.复杂度:13.5

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1