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诺氟沙星

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 海关数据
  • 结构与计算化学
  • 上游产品
  • 下游产品

诺氟沙星 基本信息

中文名称：
诺氟沙星 
中文别名：
氟哌酸;
1-乙基-6-氟-1,4-二氢-4-氧代-7-(1-哌嗪基)-3-喹啉羧酸;
诺氟沙星 
英文名称：
Norfloxacin
英文别名：
norfloxacin;
1-ethyl-6-fluoro-7-piperazino-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid;
1-ethyl-6-fluoro-4-oxo-7-piperazinyl-1,4-dihydro-quinoline-3-carboxylic acid;
am-715;
Zomxin;
Utinor;
Barazan;
Noflo;
Zoroxin;
Norfloxacin;
Fulgram;
noroxin;
4803P 
CAS No.：
70458-96-7
分 子 式：

C16H18FN3O3

分 子 量：
319.33
精确分子量：
319.13300
PSA：
74.57000
MDL：
MFCD00079532
EINECS：
274-614-4
InChI：
InChI=1/C16H18FN3O3.C3H6O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20;1-2(4)3(5)6/h7-9,18H,2-6H2,1H3,(H,22,23);2,4H,1H3,(H,5,6)
危险品标志：

 

风险术语：

 

安全术语：

 

分子结构式：
SDS：
查看

诺氟沙星 制备方法及用途

制备方法

邻二氯苯经硝化,或对硝基氯苯经氯化均可得3,4-二氯硝基苯。再在二甲亚砜中,和氟化钾回流,氟化得3-氯-4-氟硝基苯。在盐酸或乙酸水溶液存在下,用铁粉还原成3-氯-4-氟苯胺。接着和原甲酸三乙酯及丙二酸二乙酯(生成乙氧基亚甲基丙二酸二乙酯)在硝酸铵存在下回流,得缩合产物。在液体石蜡或二苯醚中加热环合,生成7-氯-6-氟-4-羟基喹啉-3-羧酸乙酯。进行乙基化后,再水解得乙基化产物。最后与哌嗪缩合得诺氟沙星。其工艺比较成熟,收率较高,一般能达到40%～65%,但7位引入哌嗪基时,6位氟原子被取代的副产物可占25%,分离困难,影响收率。以对硝基氯苯计总收率为8%以上。 在引入吡嗪环前,1-乙基-6-氟-7-氯-1,4-二氢-4-氧代喹啉-8-羧酸乙酯先和氟硼酸或三氟化硼-乙醚或乙酸硼反应,使4位上的羰基形成硼螯合物,然后再引入吡嗪基,可使7位氟被置换的副反应减少,收率可提高15%以上,且产品的质量改善。 诺氟沙星的合成,国内外研究较多,但真正用于工业生产的却不多。其合成路线的改进主要体现在两个方面。一是对成环工艺进行改进,二是在哌嗪基的引入上做些文章。

合成制备方法

邻二氯苯经硝化，或对硝基氯苯经氯化均可得3，4-二氯硝基苯。再在二甲亚砜中，和氟化钾回流，氟化得3-氯-4-氟硝基苯。在盐酸或乙酸水溶液存在下，用铁粉还原成3-氯-4-氟苯胺。接着和原甲酸三乙酯及丙二酸二乙酯(生成乙氧基亚甲基丙二酸二乙酯)在硝酸铵存在下回流，得缩合产物。在液体石蜡或二苯醚中加热环合，生成7-氯-6-氟-4-羟基喹啉-3-羧酸乙酯。进行乙基化后，再水解得乙基化产物。最后与哌嗪缩合得诺氟沙星。其工艺比较成熟，收率较高，一般能达到40%～65%，但7位引入哌嗪基时，6位氟原子被取代的副产物可占25%，分离困难，影响收率。以对硝基氯苯计总收率为8%以上。


在引入吡嗪环前，1-乙基-6-氟-7-氯-1，4-二氢-4-氧代喹啉-8-羧酸乙酯先和氟硼酸或三氟化硼-乙醚或乙酸硼反应，使4位上的羰基形成硼螯合物，然后再引入吡嗪基，可使7位氟被置换的副反应减少，收率可提高15%以上，且产品的质量改善。

 


诺氟沙星的合成，国内外研究较多，但真正用于工业生产的却不多。其合成路线的改进主要体现在两个方面。一是对成环工艺进行改进，二是在哌嗪基的引入上做些文章。

用途简介

适用于敏感菌所致的呼吸道、尿路感染、淋病、前列腺炎。

用途

1.对大肠杆菌、肺炎杆菌、产气杆菌、阴沟杆菌、变形杆菌、沙门氏杆菌、志贺氏菌属及雷氏菌属等遥植树菌具有强大的抗菌作用。临床用于敏感菌所致的泌尿系统、肠道、呼吸系统、外科、妇科、五官科及皮肤科等感受染性疾病。还用于治疗淋病。

2.具有广谱高效的抗菌作用，治疗范围广，口服吸收好，毒性低，临床上主要用于尿路感染、胆道感染、肠道感染的治疗，疗效显著。

诺氟沙星 物化性质

外观与性状：
灰白色至淡黄色结晶粉末
密度：
1.344 g/cm3
熔点：
220°C
沸点：
555.8ºC at 760 mmHg
闪点：
289.9ºC
存储条件/存储方法：
通风低温干燥
稳定性相关：

常温常压下稳定，远离氧化剂。

其它信息：

1.       性状：类白色至淡黄色结晶性粉末。无臭，味微苦。

2.       密度（g/mL,25/4℃）：未确定

3.       相对蒸汽密度（g/mL,空气=1）：未确定

4.       熔点（ºC）：227-228

5.       沸点（ºC,常压）：556

6.       沸点（ºC,5.2kPa）：未确定

7.       折射率：未确定

8.       闪点（ºC）：290

9.       比旋光度（º）：未确定

10.    自燃点或引燃温度（ºC）：未确定

11.    蒸气压（kPa,25ºC）：未确定

12.    饱和蒸气压（kPa,60ºC）：未确定

13.    燃烧热（KJ/mol）：未确定

14.    临界温度（ºC）：未确定

15.    临界压力（KPa）：未确定

16.    油水（辛醇/水）分配系数的对数值：未确定

17.    爆炸上限（%,V/V）：未确定

18.    爆炸下限（%,V/V）：未确定

19.    溶解性：易溶于水，水中溶解度为10%（ g/ml，25℃），极微溶于乙醇，几乎不溶于甲醇，氯仿。

诺氟沙星 安全信息

海关代码：
2933990090
WGK_Germany：
2
德国有关水污染物质的分类清单
危险类别码：
R20/21/22
安全说明：
26-37/39
RTECS号：
VB2005000
危险标志：
Xn: Harmful;

诺氟沙星 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VB2005000
CHEMICAL NAME :
3-Quinolinecarboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-
CAS REGISTRY NUMBER :
70458-96-7
BEILSTEIN REFERENCE NO. :
0567897
LAST UPDATED :
199612
DATA ITEMS CITED :
33
MOLECULAR FORMULA :
C16-H18-F-N3-O3
MOLECULAR WEIGHT :
319.37
WISWESSER LINE NOTATION :
T66 BN EVJ B2 DVQ HF I- DT6M DNTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
94 mg/kg/13D-I
TOXIC EFFECTS :
Musculoskeletal - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
48 mg/kg/2D-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal Behavioral - muscle weakness Musculoskeletal - joints
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
245 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1064 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
220 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
470 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1400 mg/kg/2W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - retinal changes (pigmentary depositions, retinitis, other)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
9 gm/kg/30D-I
TOXIC EFFECTS :
Musculoskeletal - joints
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1375 mg/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - behavioral
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2750 mg/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
20 gm/kg
SEX/DURATION :
male 61 day(s) pre-mating female 15 day(s) pre-mating - 6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
10 gm/kg
SEX/DURATION :
male 61 day(s) pre-mating female 15 day(s) pre-mating - 6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1250 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2 gm/kg
SEX/DURATION :
female 10-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Endocrine - estrogenic Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
4650 mg/kg
SEX/DURATION :
female 20-50 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1625 mg/kg
SEX/DURATION :
female 13 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1300 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1300 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1300 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
Micronucleus test

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
310 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 221,263,1989
毒理学数据：

小鼠，大鼠LD50（mg/kg）：全部＞4000经口；全部1500皮下注射；470，＞500肌内注射；220，270静脉注射。

诺氟沙星 MSDS

Section I.Chemical Product and Company Identification
    Chemical Name Norfloxacin
    Portland OR
    Synonym        3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-    
    dihydro-4-oxo-7-(1-piperazinyl)- (CA INDEX NAME);
    1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-
    3-quinolinecarboxylic Acid
    Chemical Formula        C16H18FN3O3    
    CAS Number        70458-96-7    
Section II.        Composition and Information on Ingredients    
    Toxicology Data
    Chemical Name        CAS Number Percent (%)        TLV/PEL    
    Min. 98.0 Not available.        Rat LD50 (oral) >4 gm/kg    
    Norfloxacin        70458-96-7    
    (HPLC,T)        Mouse LD50 (intraperitoneal) 1064    
    mg/kg
    Rat LD50 (intravenous) 245 mg/kg
Section III. Hazards Identification
    No specific information is available in our data base regarding the toxic effects of this material for humans. However,
    Acute Health Effects
    exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if
    inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling
    this compound.
    CARCINOGENIC EFFECTS : Not available.
    Chronic Health Effects
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Not available.
    DEVELOPMENTAL TOXICITY: Reproductive effects.
    Rat TDLo Oral 1375 mg/kg, female 7-17 days of pregnancy
    Toxic Effects:
    Specific Developmental Abnormalities - Musculoskeletal system
    Effects on Newborn - Behavioral
    Rabbit Oral 1300 mg/kg, female 6-18 days of pregnancy
    Toxic Effects:
    Effects on Fertility - Litter size
    Effects on Embryo or Fetus - Fetotoxicity
    Effects on Embryo or Fetus - Fetal death
    Rabbit Oral 1625 mg/kg, female 13 days prior to mating
    Toxic Effects:
    Maternal Effects - Ovaries, fallopian tubes
    Maternal Effects - Uterus, cervix, vagina
    Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.
Section IV.        First Aid Measures    
    Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15    
    minutes. Get medical attention.
    Skin Contact        In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing    
    before reuse. Thoroughly clean shoes before reuse. Get medical attention.
    Inhalation        If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or    
    waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
    improve.
    INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
    Ingestion
    Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
    resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
    material was ingested; the absence of such signs, however, is not conclusive.
    Continued on Next Page
    Norfloxacin
Section V.        Fire and Explosion Data    
    Not available.
    Flammability        May be combustible at high temperature.        Auto-Ignition    
    Flammable Limits        Not available.    
    Flash Points        Not available.    
    Combustion Products        These products are toxic carbon oxides (CO, CO2), nitrogen oxides (NO, NO2), halogenated compounds.    
    WARNING: Highly toxic HF gas is produced during combustion.
    Fire Hazards        Not available.    
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards
    Risks of explosion of the product in presence of static discharge: Not available.
    Fire Fighting Media
    SMALL FIRE: Use DRY chemical powder.
    LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
    and Instructions
    Consult with local fire authorities before attempting large scale fire-fighting operations.
Section VI.        Accidental Release Measures    
    Spill Cleanup        Hygroscopic material.    
    Use a shovel to put the material into a convenient waste disposal container. Finish cleaning the spill by rinsing any
    Instructions
    contaminated surfaces with copious amounts of water. Consult federal, state, and/or local authorities for assistance on
    disposal.
Section VII. Handling and Storage
    HYGROSCOPIC. Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container and store
    Handling and Storage
    in a dry, cool place. Avoid excessive heat and light. Do not breathe dust.
    Information
    Always store away from incompatible compounds such as oxidizing agents, moisture.
Section VIII. Exposure Controls/Personal Protection
    Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended    
    exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
    below the exposure limit.
    Personal Protection        Splash goggles. Lab coat. Dust respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a    
    specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent.
    Not available.
    Exposure Limits
Section IX. Physical and Chemical Properties
    Physical state @ 20°C        Solid. (Very pale yellow ~ pale yellow,        Solubility        Solubility at 25°C (mg/ml): water 0.28;    
    crystal ~ powder.)
    methanol 0.98; ethanol 1.9; acetone 5.1;
    chloroform 5.5; diethyl ether 0.1; benzene
    Not available.
    Specific Gravity
    0.15; ethyl acetate 0.94; octyl alcohol 5.1;
    glacial acetic acid 340.
    Solubility in water is pH dependent,
    increasing sharply at pH <5 or at pH >10.
    Molecular Weight        319.33        Partition Coefficient        LOG Pow: 0.46    
    Boiling Point        Not available.        Not applicable.    
    Vapor Pressure
    Melting Point        221°C (429.8°F)        Vapor Density        Not available.    
    Not available.        Not available.    
    Refractive Index        Volatility    
    Critical Temperature        Not available.        Odor        Not available.    
    Not available.        Not available.    
    Viscosity        Taste    
Section X.        Stability and Reactivity Data    
This material is stable if stored under proper conditions. (See Section VII for instructions)
    Stability
    Conditions of Instability        Avoid excessive heat and light. Hygroscopic; keep container tightly closed.    
    Incompatibilities        Reactive with oxidizing agents, moisture.    
    Continued on Next Page
    Norfloxacin
Section XI. Toxicological Information
    RTECS Number        VB2005000    
    Eye Contact. Ingestion. Inhalation.
    Routes of Exposure
    Toxicity Data        Rat LD50 (oral) >4 gm/kg    
    Mouse LD50 (intraperitoneal) 1064 mg/kg
    Rat LD50 (intravenous) 245 mg/kg
    Chronic Toxic Effects        CARCINOGENIC EFFECTS : Not available.    
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Not available.
    DEVELOPMENTAL TOXICITY: Reproductive effects.
    Rat TDLo Oral 1375 mg/kg, female 7-17 days of pregnancy
    Toxic Effects:
    Specific Developmental Abnormalities - Musculoskeletal system
    Effects on Newborn - Behavioral
    Rabbit Oral 1300 mg/kg, female 6-18 days of pregnancy
    Toxic Effects:
    Effects on Fertility - Litter size
    Effects on Embryo or Fetus - Fetotoxicity
    Effects on Embryo or Fetus - Fetal death
    Rabbit Oral 1625 mg/kg, female 13 days prior to mating
    Toxic Effects:
    Maternal Effects - Ovaries, fallopian tubes
    Maternal Effects - Uterus, cervix, vagina
    Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.
    Acute Toxic Effects        No specific information is available in our data base regarding the toxic effects of this material for humans. However,    
    exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if
    inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling this
    compound.
Section XII.        Ecological Information    
    Not available.
    Ecotoxicity
    Not available.
    Environmental Fate
Section XIII. Disposal Considerations
    Waste Disposal        Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a    
    combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
    federal, state and local regulations when disposing of the substance.
Section XIV. Transport Information
    DOT Classification        Not a DOT controlled material (United States).    
    PIN Number        Not applicable.    
    Proper Shipping Name        Not applicable.    
    Packing Group (PG)        Not applicable.    
    DOT Pictograms
Section XV. Other Regulatory Information and Pictograms
    TSCA Chemical Inventory        This product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40    
    CFR 720.36 (C) for those products not on the inventory list:
    (EPA)
    (i) These products are supplied solely for use in research and development by or under the supervision of a technically
    qualified individual as defined in 40 CFR 720.0 et sec.
    (ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
    supplied on an MSDS sheet.
    WHMIS Classification        On DSL.    
    (Canada)
    EINECS Number (EEC) 274-614-4
    EEC Risk Statements        Not available.    
    Japanese Regulatory Data Not available.
    Continued on Next Page

SECTION 16 - ADDITIONAL INFORMATION
N/A

诺氟沙星 海关数据

中国海关编码：2933990090

概述：
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素：
品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
摘要/Summary：
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

诺氟沙星 分子结构与计算化学数据

分子结构数据

1、   摩尔折射率：80.70

2、   摩尔体积（cm3/mol）：237.4

3、   等张比容（90.2K）：641.2

4、   表面张力（dyne/cm）：53.1

5、   极化率（10-24cm3）：31.99

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:2

3.氢键受体数量:7

4.可旋转化学键数量:3

5.互变异构体数量:无

6.拓扑分子极性表面积72.9

7.重原子数量:23

8.表面电荷:0

9.复杂度:519

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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